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    Serhl serine hydrolase-like [ Mus musculus (house mouse) ]

    Gene ID: 68607, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Serhlprovided by MGI
    Official Full Name
    serine hydrolase-likeprovided by MGI
    Primary source
    MGI:MGI:1890404
    See related
    Ensembl:ENSMUSG00000058586 AllianceGenome:MGI:1890404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610008B10Rik; 1110019M09Rik
    Summary
    Predicted to enable hydrolase activity. Located in cytoplasmic vesicle. Is expressed in choroid invagination; diencephalon roof plate; and metencephalon part of 4th ventricle choroid plexus. Orthologous to several human genes including SERHL2 (serine hydrolase like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 23.5), colon adult (RPKM 16.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Serhl in Genome Data Viewer
    Location:
    15 E1; 15 39.32 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82984394..83000876)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83100192..83116676)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Nfat activating molecule with ITAM motif 1 Neighboring gene STARR-positive B cell enhancer ABC_E7401 Neighboring gene STARR-positive B cell enhancer ABC_E3149 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:82873210-82873393 Neighboring gene predicted gene, 32620 Neighboring gene STARR-seq mESC enhancer starr_39309 Neighboring gene STARR-positive B cell enhancer ABC_E3150 Neighboring gene predicted gene, 41366 Neighboring gene STARR-positive B cell enhancer ABC_E7402 Neighboring gene ribosomal RNA processing 7 homolog A Neighboring gene polymerase (DNA-directed), delta interacting protein 3 Neighboring gene RNA U12, small nuclear

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo. Sadusky TJ, et al. Genomics, 2001 Apr 1. PMID 11352564
    2. Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles. Dong B, et al. Development, 2018 Oct 8. PMID 30237242, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine hydrolase-like protein
    Names
    SHL

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023475.3 → NP_075964.1  serine hydrolase-like protein

      See identical proteins and their annotated locations for NP_075964.1

      Status: VALIDATED

      Source sequence(s)
      AK003827, BC064069, BY082798
      Consensus CDS
      CCDS49682.1
      UniProtKB/Swiss-Prot
      Q9DCZ8, Q9EPB5
      UniProtKB/TrEMBL
      Q3U3G8, Q80XK9
      Related
      ENSMUSP00000077345.5, ENSMUST00000078218.11
      Conserved Domains (2) summary
      COG0596
      Location:15 → 303
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:28 → 129
      Abhydrolase_5; Alpha/beta hydrolase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      82984394..83000876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248725.2 → XP_030104585.1  serine hydrolase-like protein isoform X1

    RNA

    1. XR_384036.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPB5.1 GenPept UniProtKB/Swiss-Prot:Q9EPB5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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