Tnk1 tyrosine kinase, non-receptor, 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnk1provided by MGI
Official Full Name: tyrosine kinase, non-receptor, 1provided by MGI
Primary source: MGI:MGI:1930958
See related: Ensembl:ENSMUSG00000001583 AllianceGenome:MGI:1930958
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kos1; Tnk1a; Tnk1b
Summary: Enables ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in negative regulation of Ras protein signal transduction; negative regulation of cell growth; and protein autophosphorylation. Located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; pituitary gland; respiratory system; and thymus. Orthologous to human TNK1 (tyrosine kinase non receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 21.8), large intestine adult (RPKM 15.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.9 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69741389..69749556, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69850563..69858730, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Novel Putative Role of TNK1 in Atherosclerotic Inflammation Implicating the Tyk2/STAT1 Pathway.
Title: A Novel Putative Role of TNK1 in Atherosclerotic Inflammation Implicating the Tyk2/STAT1 Pathway.
TNK1 was found to be deregulated in the gut in murine and porcine trauma models and human inflammatory bowel disease. Thus, TNK1 might be a target during MODS to prevent damage in several organs, notably the gut.
Title: Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.
The activated TNK1 potentiates JAK-STAT signaling through dual phosphorylation of STAT1 at tyrosine 701 and serine 727 amino acid positions.
Title: Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.
cellular stress reverses the repression of Tnk1/Kos1 and induces its expression through increased high affinity interactions between nuclear proteins Sp1, Sp3, AP2 and MED1 for the m-Tnk1 promoter
Title: Functional characterization of the murine Tnk1 promoter.
Tnk1/Kos1 is a tumor suppressor that functions to down-regulate Ras activity
Title: Tnk1/Kos1 knockout mice develop spontaneous tumors.
data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity
Title: Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: non-receptor tyrosine-protein kinase TNK1

Names: kinase of embryonic stem cells; non-receptor tyrosine kinase

NP_114086.3

EC 2.7.10.2

XP_006534617.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031880.3 → NP_114086.3 non-receptor tyrosine-protein kinase TNK1

See identical proteins and their annotated locations for NP_114086.3

Status: VALIDATED

Source sequence(s)

AK033440, AK167292, BB676903, BX528991

Consensus CDS

CCDS24917.1

UniProtKB/Swiss-Prot

Q8CCC4, Q8K0X9, Q91V11, Q99ML2

UniProtKB/TrEMBL

Q5F2B4

Related

ENSMUSP00000001626.4, ENSMUST00000001626.10

Conserved Domains (4) summary

cd09539
Location:16 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

cl17036
Location:395 → 436

SH3; Src Homology 3 domain superfamily

cl21453
Location:120 → 380

PKc_like; Protein Kinases, catalytic domain

cl21463
Location:624 → 663

UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69741389..69749556 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534554.3 → XP_006534617.1 non-receptor tyrosine-protein kinase TNK1 isoform X1

See identical proteins and their annotated locations for XP_006534617.1

UniProtKB/Swiss-Prot

Q8CCC4, Q8K0X9, Q91V11, Q99ML2

UniProtKB/TrEMBL

Q5F2B4

Related

ENSMUSP00000104268.2, ENSMUST00000108628.8

Conserved Domains (4) summary

cd09539
Location:16 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

cl17036
Location:395 → 436

SH3; Src Homology 3 domain superfamily

cl21453
Location:120 → 380

PKc_like; Protein Kinases, catalytic domain

cl21463
Location:624 → 663

UBA_like_SF; UBA domain-like superfamily