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    Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 [ Mus musculus (house mouse) ]

    Gene ID: 320707, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Atp2b3provided by MGI
    Official Full Name
    ATPase, Ca++ transporting, plasma membrane 3provided by MGI
    Primary source
    MGI:MGI:1347353
    See related
    Ensembl:ENSMUSG00000031376 AllianceGenome:MGI:1347353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pmca3; 6430519O13Rik
    Summary
    Predicted to enable P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration and PDZ domain binding activity. Predicted to be involved in calcium ion export across plasma membrane and regulation of cytosolic calcium ion concentration. Predicted to be located in membrane raft; parallel fiber; and plasma membrane. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and intracellular membrane-bounded organelle. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1. Orthologous to human ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 35.0), genital fat pad adult (RPKM 15.6) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp2b3 in Genome Data Viewer
    Location:
    X A7.3; X 37.33 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72546356..72632267)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73502749..73573275)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene HAUS augmin-like complex, subunit 7 Neighboring gene biglycan Neighboring gene cyclin Q, pseudogene 1 Neighboring gene predicted gene, 46680 Neighboring gene dual specificity phosphatase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†. Savy V, et al. Biol Reprod, 2022 Dec 10. PMID 36130203, Free PMC Article
    2. The plasma membrane calcium pump in health and disease. Brini M, et al. FEBS J, 2013 Nov. PMID 23413890
    3. Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons. Krizaj D, et al. J Comp Neurol, 2002 Sep 9. PMID 12209837, Free PMC Article
    4. Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function. Garcia ML, et al. Front Biosci, 1999 Dec 1. PMID 10577388
    5. Differential regulation of the apical plasma membrane Ca(2+) -ATPase by protein kinase A in parotid acinar cells. Baggaley E, et al. J Biol Chem, 2007 Dec 28. PMID 17938178

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables PDZ domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in parallel fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    plasma membrane calcium-transporting ATPase 3
    NP_001297466.1
    NP_796210.2
    XP_006528144.1
    XP_006528147.1
    XP_006528149.1
    XP_011245911.1
    XP_011245912.1
    XP_011245913.1
    XP_011245914.1
    XP_011245915.1
    XP_011245916.1
    XP_030107234.1
    XP_036017880.1
    XP_036017881.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310537.1 → NP_001297466.1  plasma membrane calcium-transporting ATPase 3 isoform 2

      See identical proteins and their annotated locations for NP_001297466.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK032322, AL805924, AW048876, BB643948
      Consensus CDS
      CCDS85778.1
      UniProtKB/TrEMBL
      Q0VF54, Q8C048
      Related
      ENSMUSP00000033744.6, ENSMUST00000033744.12
      Conserved Domains (7) summary
      TIGR01517
      Location:19 → 1061
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:164 → 462
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:877 → 1055
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51 → 121
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1100 → 1114
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:684 → 803
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:523 → 612
      Cation_ATPase; Cation transport ATPase (P-type)

    2. NM_177236.4 → NP_796210.2  plasma membrane calcium-transporting ATPase 3 isoform 1

      See identical proteins and their annotated locations for NP_796210.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AK032322, AK045516, AL805924
      Consensus CDS
      CCDS30205.1
      UniProtKB/TrEMBL
      Q0VF54, Q0VF55
      Related
      ENSMUSP00000085775.2, ENSMUST00000088429.8
      Conserved Domains (7) summary
      TIGR01517
      Location:19 → 1061
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:164 → 462
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:877 → 1055
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51 → 121
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1100 → 1147
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:684 → 803
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:523 → 612
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72546356..72632267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161988.1 → XP_036017881.1  plasma membrane calcium-transporting ATPase 3 isoform X6

      UniProtKB/TrEMBL
      Q0VF54
      Conserved Domains (2) summary
      TIGR01517
      Location:19 → 1061
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1100 → 1114
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    2. XM_006528081.3 → XP_006528144.1  plasma membrane calcium-transporting ATPase 3 isoform X1

      See identical proteins and their annotated locations for XP_006528144.1

      UniProtKB/TrEMBL
      Q0VF54
      Conserved Domains (2) summary
      TIGR01517
      Location:19 → 1061
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1100 → 1175
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    3. XM_011247612.2 → XP_011245914.1  plasma membrane calcium-transporting ATPase 3 isoform X2

      UniProtKB/TrEMBL
      Q0VF54
      Conserved Domains (2) summary
      TIGR01517
      Location:19 → 1047
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1086 → 1161
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    4. XM_006528084.5 → XP_006528147.1  plasma membrane calcium-transporting ATPase 3 isoform X4

      UniProtKB/TrEMBL
      A2ALL9, Q0VF54
      Related
      ENSMUSP00000110123.2, ENSMUST00000114479.2
      Conserved Domains (2) summary
      TIGR01517
      Location:19 → 1061
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1100 → 1145
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    5. XM_011247614.4 → XP_011245916.1  plasma membrane calcium-transporting ATPase 3 isoform X5

      UniProtKB/TrEMBL
      Q0VF54
      Conserved Domains (2) summary
      TIGR01517
      Location:19 → 1047
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1086 → 1131
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    6. XM_006528086.4 → XP_006528149.1  plasma membrane calcium-transporting ATPase 3 isoform X7

      UniProtKB/TrEMBL
      Q0VF54
      Conserved Domains (2) summary
      TIGR01517
      Location:19 → 1061
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1100 → 1114
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    7. XM_030251374.2 → XP_030107234.1  plasma membrane calcium-transporting ATPase 3 isoform X8

      UniProtKB/TrEMBL
      Q0VF54
      Conserved Domains (2) summary
      TIGR01517
      Location:19 → 1047
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1086 → 1100
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    8. XM_011247613.3 → XP_011245915.1  plasma membrane calcium-transporting ATPase 3 isoform X3

      UniProtKB/TrEMBL
      Q0VF54
      Conserved Domains (2) summary
      TIGR01517
      Location:19 → 1047
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1086 → 1132
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    9. XM_036161987.1 → XP_036017880.1  plasma membrane calcium-transporting ATPase 3 isoform X2

      UniProtKB/TrEMBL
      Q0VF54
      Conserved Domains (2) summary
      TIGR01517
      Location:19 → 1047
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1086 → 1161
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    10. XM_011247610.2 → XP_011245912.1  plasma membrane calcium-transporting ATPase 3 isoform X1

      See identical proteins and their annotated locations for XP_011245912.1

      UniProtKB/TrEMBL
      Q0VF54
      Conserved Domains (2) summary
      TIGR01517
      Location:19 → 1061
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1100 → 1175
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    11. XM_011247609.4 → XP_011245911.1  plasma membrane calcium-transporting ATPase 3 isoform X1

      See identical proteins and their annotated locations for XP_011245911.1

      UniProtKB/TrEMBL
      Q0VF54
      Conserved Domains (2) summary
      TIGR01517
      Location:19 → 1061
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1100 → 1175
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    12. XM_011247611.3 → XP_011245913.1  plasma membrane calcium-transporting ATPase 3 isoform X1

      See identical proteins and their annotated locations for XP_011245913.1

      UniProtKB/TrEMBL
      Q0VF54
      Conserved Domains (2) summary
      TIGR01517
      Location:19 → 1061
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1100 → 1175
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    RNA

    1. XR_004940342.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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