Khdc1a KH domain containing 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Khdc1aprovided by MGI
Official Full Name: KH domain containing 1Aprovided by MGI
Primary source: MGI:MGI:2676610
See related: Ensembl:ENSMUSG00000067750 AllianceGenome:MGI:2676610
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ndg1; C88118; AU014713
Summary: Enables identical protein binding activity and poly(U) RNA binding activity. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to act upstream of or within apoptotic process. Located in cytoplasm. Is expressed in several structures, including early conceptus; gonad; intestine; liver; and lung. Orthologous to human KHDC1L (KH domain containing 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 1.1), ovary adult (RPKM 0.6) and 6 other tissues See more
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Genomic context

Location:: 1 A4; 1 6.59 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (21419901..21422423)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (21349677..21352199)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The paper describes the connection of this gene to translational machinery including CPEB
Title: KHDC1B is a novel CPEB binding partner specifically expressed in mouse oocytes and early embryos.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234077

NoName (e-PCR)
- UniSTS:234078

Khdc1a (e-PCR), detects polymorphism
- UniSTS:548005

Khdc1a (e-PCR), detects polymorphism
- UniSTS:548006

C88118 (e-PCR)
- UniSTS:178362

NoName (e-PCR)
- UniSTS:488652

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables poly(U) RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: KH homology domain-containing protein 1A

Names: KH homology domain containing 1A; Nur77 downstream protein 1; nur77 downstream gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.