Metrn meteorin, glial cell differentiation regulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Metrnprovided by MGI
Official Full Name: meteorin, glial cell differentiation regulatorprovided by MGI
Primary source: MGI:MGI:1917333
See related: Ensembl:ENSMUSG00000002274 AllianceGenome:MGI:1917333
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hyrac; EyeLinc16; 1810034B16Rik
Summary: Predicted to enable hormone activity. Acts upstream of or within glial cell differentiation and positive regulation of axonogenesis. Located in extracellular space. Is expressed in several structures, including eye; genitourinary system; liver; midgut; and nervous system. Orthologous to human METRN (meteorin, glial cell differentiation regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 88.3), CNS E11.5 (RPKM 57.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.89 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (26013545..26016019, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (25794571..25797045, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Meteorin is a novel regulator of Nodal transcription
Title: Meteorin regulates mesendoderm development by enhancing nodal expression.
Recombinant Metrn infused into the stroke-damaged brain stimulates cell proliferation in subventricular zone, promotes neuroblast migration, and increases the number of immature and mature neurons in the ischemic striatum.
Title: Meteorin is a chemokinetic factor in neuroblast migration and promotes stroke-induced striatal neurogenesis.
promotes both cortical stem cell differentiation and retinal glia development via Jak-STAT3 pathway
Title: Meteorin promotes the formation of GFAP-positive glia via activation of the Jak-STAT3 pathway.
Data show that Meteorin is expressed in the central nervous system both during development and in adult mice.
Title: Characterization of Meteorin--an evolutionary conserved neurotrophic factor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in glial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within radial glial cell differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: meteorin

Names: hypoxia/reoxygenation regulatory factor in astrocytes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.