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    Ces1h carboxylesterase 1H [ Mus musculus (house mouse) ]

    Gene ID: 75704, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Ces1hprovided by MGI
    Official Full Name
    carboxylesterase 1Hprovided by MGI
    Primary source
    MGI:MGI:1922954
    See related
    Ensembl:ENSMUSG00000074156 AllianceGenome:MGI:1922954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310039D24Rik
    Summary
    Predicted to enable carboxylic ester hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in endoplasmic reticulum and lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 1.8), testis adult (RPKM 0.4) and 1 other tissue See more
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    Genomic context

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    See Ces1h in Genome Data Viewer
    Location:
    8 C5; 8 45.38 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94078468..94106405, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93351840..93379777, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 1F Neighboring gene carboxylesterase 1G Neighboring gene STARR-seq mESC enhancer starr_22334 Neighboring gene STARR-seq mESC enhancer starr_22335 Neighboring gene STARR-seq mESC enhancer starr_22336 Neighboring gene predicted gene, 30132 Neighboring gene STARR-seq mESC enhancer starr_22337 Neighboring gene carboxylesterase 5A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in medium-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of bile acid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reverse cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    carboxylesterase 1H

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370830.1 → NP_001357759.1  carboxylesterase 1H precursor

      Status: VALIDATED

      Source sequence(s)
      AC162945, AC162949
      Consensus CDS
      CCDS90436.1
      UniProtKB/TrEMBL
      D3Z298
      Related
      ENSMUSP00000121729.3, ENSMUST00000145041.4
      Conserved Domains (1) summary
      pfam00135
      Location:24 → 546
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      94078468..94106405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531545.2 → XP_006531608.1  carboxylesterase 1H isoform X1

      See identical proteins and their annotated locations for XP_006531608.1

      Conserved Domains (1) summary
      pfam00135
      Location:2 → 462
      COesterase; Carboxylesterase family

    2. XM_006531546.2 → XP_006531609.1  carboxylesterase 1H isoform X2

      See identical proteins and their annotated locations for XP_006531609.1

      Conserved Domains (1) summary
      pfam00135
      Location:1 → 410
      COesterase; Carboxylesterase family
    Nucleotide Protein Strain
    Heading Accession and Version

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