Chst8 carbohydrate sulfotransferase 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chst8provided by MGI
Official Full Name: carbohydrate sulfotransferase 8provided by MGI
Primary source: MGI:MGI:1916197
See related: Ensembl:ENSMUSG00000060402 AllianceGenome:MGI:1916197
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1500011J21Rik
Summary: Enables N-acetylgalactosamine 4-O-sulfotransferase activity. Acts upstream of or within proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including foregut; genitourinary system; heart; nervous system; and pelvic girdle skeleton. Human ortholog(s) of this gene implicated in peeling skin syndrome. Orthologous to human CHST8 (carbohydrate sulfotransferase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 27.2), adrenal adult (RPKM 7.4) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B2; 7 20.53 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (34373893..34512136, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (34674468..34812711, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings indicate that the Chst8 transcript level affects the glycosaminoglycan environment of the cellular prion protein, and as a consequence its ability for conversion into PrP(Sc).
Title: Variation in Chst8 gene expression level affects PrPC to PrPSc conversion efficiency in prion-infected Mov cells.
analysis of enzymatic properties and expression of GalNAc-4-sulfotransferase-1 and GalNAc-4-sulfotransferase-2
Title: Differential expression and enzymatic properties of GalNAc-4-sulfotransferase-1 and GalNAc-4-sulfotransferase-2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

AI426009 (e-PCR)
- UniSTS:179590

D7Mit156 (e-PCR), detects polymorphism
- UniSTS:116710

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetylgalactosamine 4-O-sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetylgalactosamine 4-O-sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptide hormone processing	TAS Traceable Author Statement more info	PubMed
involved_in proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in sulfur compound metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carbohydrate sulfotransferase 8

Names: GalNAc4ST-1; N-acetylgalactosamine-4-O-sulfotransferase 1; carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8; galNAc-4-O-sulfotransferase 1; galNAc-4-ST1

NP_780349.3

EC 2.8.2.-

XP_006540400.1

EC 2.8.2.-

XP_006540403.1

EC 2.8.2.-

XP_030098815.1

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.