Ndufa4l2 Ndufa4, mitochondrial complex associated like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndufa4l2provided by MGI
Official Full Name: Ndufa4, mitochondrial complex associated like 2provided by MGI
Primary source: MGI:MGI:3039567
See related: Ensembl:ENSMUSG00000040280 AllianceGenome:MGI:3039567
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to be part of mitochondrial respiratory chain complex IV. Is expressed in several structures, including brain; heart; integumental system; nose; and reproductive system. Orthologous to human NDUFA4L2 (NDUFA4 mitochondrial complex associated like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 37.3), adrenal adult (RPKM 32.7) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 74.51 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127345143..127353023)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127509274..127517154)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia.
Title: Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia.
Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force.
Title: Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force.
The results demonstrated that the upregulation of NDUFA4L2 ameliorated the apoptosis of NP cells by repressing excessive mitophagy, which ultimately alleviated IVDD. These findings show for the first time that NDUFA4L2 and mitophagy may be potential therapeutic targets for IVDD.
Title: Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy.
Induction of the mitochondrial NDUFA4L2 protein by HIF-1alpha decreases oxygen consumption by inhibiting Complex I activity.
Title: Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ndufa4l2 (e-PCR), detects polymorphism
- UniSTS:546886

RH125781 (e-PCR)
- UniSTS:162528

RH126912 (e-PCR)
- UniSTS:208629

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
part_of mitochondrial respiratory chain complex IV	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

Names: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098789.1 → NP_001092259.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

See identical proteins and their annotated locations for NP_001092259.1

Status: VALIDATED

Source sequence(s)

BC099496, BY336656

Consensus CDS

CCDS36080.1

UniProtKB/Swiss-Prot

Q4FZG9

Related

ENSMUSP00000042185.10, ENSMUST00000035735.11

Conserved Domains (1) summary

pfam06522
Location:16 → 84

B12D; NADH-ubiquinone reductase complex 1 MLRQ subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

127345143..127353023

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245154.1 → XP_030101014.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X2

Conserved Domains (1) summary

pfam06522
Location:1 → 62

B12D; NADH-ubiquinone reductase complex 1 MLRQ subunit
XM_006513834.3 → XP_006513897.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X1

Conserved Domains (1) summary

pfam06522
Location:17 → 81

B12D; NADH-ubiquinone reductase complex 1 MLRQ subunit