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    B4galt3 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 [ Mus musculus (house mouse) ]

    Gene ID: 57370, updated on 5-Mar-2024

    Summary

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    Official Symbol
    B4galt3provided by MGI
    Official Full Name
    UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3provided by MGI
    Primary source
    MGI:MGI:1928767
    See related
    Ensembl:ENSMUSG00000052423 AllianceGenome:MGI:1928767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM6; ESTM26; 9530061M23Rik
    Summary
    Predicted to enable galactosyltransferase activity. Predicted to be involved in galactosylceramide biosynthetic process and glycosylation. Predicted to be located in cytosol. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Orthologous to human B4GALT3 (beta-1,4-galactosyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 38.6), ovary adult (RPKM 29.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See B4galt3 in Genome Data Viewer
    Location:
    1 H3; 1 79.29 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171097898..171104468)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171270328..171276895)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Fc receptor, IgE, high affinity I, gamma polypeptide Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene STARR-seq mESC enhancer starr_03024 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4 Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211225-173211526 Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211857-173212158 Neighboring gene protoporphyrinogen oxidase Neighboring gene ubiquitin specific peptidase 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential gene expression of beta-1,4-galactosyltransferases I, II and V during mouse brain development. Nakamura N, et al. J Neurochem, 2001 Jan. PMID 11145975
    2. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Lo NW, et al. Glycobiology, 1998 May. PMID 9597550
    3. Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering. Tchernev VT, et al. Genomics, 1997 Feb 15. PMID 9070936
    4. Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Bettenhausen B, et al. Genomics, 1995 Aug 10. PMID 7490078
    5. Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Eddleston J, et al. Genomics, 1999 Mar 1. PMID 10051400

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice.
      Title: Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyllactosamine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactosylceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactosylceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,4-galactosyltransferase 3
    Names
    N-acetyllactosamine synthase
    UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3
    UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3; beta-1,4-galactosyltransferase III; beta4GalT-III; expressed sequence tag mouse EST 6
    UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3
    b4Gal-T3
    beta-1,4-GalTase 3
    beta-1,4-galactosyltransferase III
    beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
    beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
    beta4Gal-T3
    beta4GalT-III
    nal synthase
    neolactotriaosylceramide beta-1,4-galactosyltransferase
    NP_065604.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020579.2 → NP_065604.2  beta-1,4-galactosyltransferase 3

      See identical proteins and their annotated locations for NP_065604.2

      Status: VALIDATED

      Source sequence(s)
      AF142671, BP772898, BU703242, CD363941
      Consensus CDS
      CCDS15486.1
      UniProtKB/Swiss-Prot
      Q91YY2, Q9QY13
      UniProtKB/TrEMBL
      Q3U260
      Related
      ENSMUSP00000066353.4, ENSMUST00000064272.10
      Conserved Domains (1) summary
      cd00899
      Location:124 → 343
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171097898..171104468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YY2.1 GenPept UniProtKB/Swiss-Prot:Q91YY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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