Gid8 GID complex subunit 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gid8provided by MGI
Official Full Name: GID complex subunit 8provided by MGI
Primary source: MGI:MGI:1923675
See related: Ensembl:ENSMUSG00000027573 AllianceGenome:MGI:1923675
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Twa1; 2310003C23Rik; 4833420G11Rik
Summary: Enables protein homodimerization activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; positive regulation of cell population proliferation; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in cell junction; cytosol; and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human GID8 (GID complex subunit 8 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14 (RPKM 23.4), liver E14.5 (RPKM 22.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 103.26 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (180351874..180363392)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (180710122..180721599)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD spectroscopy of recombinant TWA1 indicated a predominantly alpha-helical protein. Gel filtration chromatography, size-exclusion chromatography (SEC) with multi-angle light scattering (SEC-MALS) and native PAGE demonstrated a propensity of untagged TWA1 to form stable dimers and, to a lesser extent, higher order oligomers.
Title: Studies of recombinant TWA1 reveal constitutive dimerization.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glucose-induced degradation protein 8 homolog

Names: GID complex subunit 8 homolog; protein C20orf11 homolog; two hybrid-associated protein 1 with RanBPM

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289651.1 → NP_001276580.1 glucose-induced degradation protein 8 homolog

See identical proteins and their annotated locations for NP_001276580.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK009106, AL732560

Consensus CDS

CCDS17185.1

UniProtKB/Swiss-Prot

Q9D7M1

Conserved Domains (2) summary

pfam08513
Location:28 → 52

LisH

pfam10607
Location:63 → 207

CLTH; CTLH/CRA C-terminal to LisH motif domain
NM_001289652.1 → NP_001276581.1 glucose-induced degradation protein 8 homolog

See identical proteins and their annotated locations for NP_001276581.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK009106, AL732560, BY131338

Consensus CDS

CCDS17185.1

UniProtKB/Swiss-Prot

Q9D7M1

Related

ENSMUSP00000029090.3, ENSMUST00000029090.9

Conserved Domains (2) summary

pfam08513
Location:28 → 52

LisH

pfam10607
Location:63 → 207

CLTH; CTLH/CRA C-terminal to LisH motif domain
NM_029607.2 → NP_083883.1 glucose-induced degradation protein 8 homolog

See identical proteins and their annotated locations for NP_083883.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK009106, AL732560, BC059022

Consensus CDS

CCDS17185.1

UniProtKB/Swiss-Prot

Q9D7M1

Related

ENSMUSP00000077753.6, ENSMUST00000078687.6

Conserved Domains (2) summary

pfam08513
Location:28 → 52

LisH

pfam10607
Location:63 → 207

CLTH; CTLH/CRA C-terminal to LisH motif domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

180351874..180363392

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162670.1 → XP_036018563.1 glucose-induced degradation protein 8 homolog isoform X2

Conserved Domains (2) summary

pfam08513
Location:28 → 52

LisH

pfam10607
Location:63 → 171

CLTH; CTLH/CRA C-terminal to LisH motif domain
XM_030252191.2 → XP_030108051.1 glucose-induced degradation protein 8 homolog isoform X1

UniProtKB/Swiss-Prot

Q9D7M1

Conserved Domains (2) summary

pfam08513
Location:28 → 52

LisH

pfam10607
Location:63 → 207

CLTH; CTLH/CRA C-terminal to LisH motif domain
XM_036162669.1 → XP_036018562.1 glucose-induced degradation protein 8 homolog isoform X1

UniProtKB/Swiss-Prot

Q9D7M1

Conserved Domains (2) summary

pfam08513
Location:28 → 52

LisH

pfam10607
Location:63 → 207

CLTH; CTLH/CRA C-terminal to LisH motif domain