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    Izumo2 IZUMO family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 75510, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Izumo2provided by MGI
    Official Full Name
    IZUMO family member 2provided by MGI
    Primary source
    MGI:MGI:1922760
    See related
    Ensembl:ENSMUSG00000066500 AllianceGenome:MGI:1922760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700023D19Rik
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human IZUMO2 (IZUMO family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 47.8) See more
    Orthologs
    human all
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    Genomic context

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    See Izumo2 in Genome Data Viewer
    Location:
    7 B3; 7 28.89 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44358122..44369272)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44708698..44719848)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 14 Neighboring gene E1A binding protein p300 pseudogene Neighboring gene RIKEN cDNA 2310016G11 gene Neighboring gene STARR-seq mESC enhancer starr_18813 Neighboring gene zinc finger protein 473 Neighboring gene STARR-positive B cell enhancer ABC_E2823 Neighboring gene vaccinia related kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous Kras(G12D). Huang J, et al. Sci Rep, 2019 Nov 20. PMID 31748650, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    izumo sperm-egg fusion protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368390.1 → NP_001355319.1  izumo sperm-egg fusion protein 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC150895
      UniProtKB/Swiss-Prot
      Q0P5Z2, Q9DA16

    2. NM_029317.2 → NP_083593.1  izumo sperm-egg fusion protein 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC150895, AK006268, BY087754
      Consensus CDS
      CCDS52235.1
      UniProtKB/Swiss-Prot
      Q9DA16
      Related
      ENSMUSP00000082543.3, ENSMUST00000085422.4
      Conserved Domains (1) summary
      pfam15005
      Location:20 → 138
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44358122..44369272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541239.2 → XP_006541302.1  izumo sperm-egg fusion protein 2 isoform X1

      Conserved Domains (1) summary
      pfam15005
      Location:21 → 157
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    2. XM_006541240.3 → XP_006541303.1  izumo sperm-egg fusion protein 2 isoform X2

      Conserved Domains (1) summary
      pfam15005
      Location:21 → 131
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    3. XM_017312361.2 → XP_017167850.1  izumo sperm-egg fusion protein 2 isoform X5

      Conserved Domains (1) summary
      pfam15005
      Location:21 → 110
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    4. XM_006541241.3 → XP_006541304.1  izumo sperm-egg fusion protein 2 isoform X3

      Conserved Domains (1) summary
      pfam15005
      Location:21 → 140
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    5. XM_017312360.2 → XP_017167849.1  izumo sperm-egg fusion protein 2 isoform X4

      Conserved Domains (1) summary
      pfam15005
      Location:21 → 110
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    6. XM_017312362.3 → XP_017167851.1  izumo sperm-egg fusion protein 2 isoform X6

      Conserved Domains (1) summary
      pfam15005
      Location:21 → 110
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DA16.2 GenPept UniProtKB/Swiss-Prot:Q9DA16

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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