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    Rmi1 RecQ mediated genome instability 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306734, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Rmi1provided by RGD
    Official Full Name
    RecQ mediated genome instability 1provided by RGD
    Primary source
    RGD:1310671
    See related
    Ensembl:ENSRNOG00000019108 AllianceGenome:RGD:1310671
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310671
    Summary
    Predicted to enable nucleotide binding activity. Predicted to be involved in double-strand break repair via homologous recombination and resolution of meiotic recombination intermediates. Predicted to act upstream of or within glucose homeostasis; reduction of food intake in response to dietary excess; and response to glucose. Predicted to be located in nucleoplasm. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in nuclear body. Orthologous to human RMI1 (RecQ mediated genome instability 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 75.5), Thymus (RPKM 74.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rmi1 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (6261961..6269947, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (6256533..6264523, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (6658285..6665618, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482765 Neighboring gene uncharacterized LOC120097836 Neighboring gene heterogeneous nuclear ribonucleoprotein K Neighboring gene microRNA 7-1 Neighboring gene Q-nucleotide N-glycosylase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RMI1 deficiency in mice protects from diet and genetic-induced obesity. Suwa A, et al. FEBS J, 2010 Feb. PMID 20050919
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within reduction of food intake in response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in resolution of DNA recombination intermediates ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RecQ family helicase-topoisomerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RecQ family helicase-topoisomerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    recQ-mediated genome instability protein 1
    Names
    RMI1, RecQ mediated genome instability 1, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400626.1 → NP_001387555.1  recQ-mediated genome instability protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      D3ZHX4

    2. NM_001400627.1 → NP_001387556.1  recQ-mediated genome instability protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      D3ZHX4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      6261961..6269947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096370.2 → XP_038952298.1  recQ-mediated genome instability protein 1 isoform X1

      UniProtKB/TrEMBL
      D3ZHX4
      Related
      ENSRNOP00000025812.4
      Conserved Domains (2) summary
      pfam08585
      Location:14 → 204
      RMI1_N; RecQ mediated genome instability protein
      pfam16099
      Location:481 → 611
      RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold

    2. XM_039096368.2 → XP_038952296.1  recQ-mediated genome instability protein 1 isoform X1

      UniProtKB/TrEMBL
      D3ZHX4
      Related
      ENSRNOP00000087376.1
      Conserved Domains (2) summary
      pfam08585
      Location:14 → 204
      RMI1_N; RecQ mediated genome instability protein
      pfam16099
      Location:481 → 611
      RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold

    3. XM_039096367.1 → XP_038952295.1  recQ-mediated genome instability protein 1 isoform X1

      UniProtKB/TrEMBL
      D3ZHX4
      Conserved Domains (2) summary
      pfam08585
      Location:14 → 204
      RMI1_N; RecQ mediated genome instability protein
      pfam16099
      Location:481 → 611
      RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold

    4. XM_006253566.5 → XP_006253628.1  recQ-mediated genome instability protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006253628.1

      UniProtKB/TrEMBL
      D3ZHX4
      Related
      ENSRNOP00000083874.1
      Conserved Domains (2) summary
      pfam08585
      Location:14 → 204
      RMI1_N; RecQ mediated genome instability protein
      pfam16099
      Location:481 → 611
      RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold

    5. XM_063276333.1 → XP_063132403.1  recQ-mediated genome instability protein 1 isoform X1

      UniProtKB/TrEMBL
      D3ZHX4
    Nucleotide Protein Strain
    Heading Accession and Version

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