Dact3 dishevelled-binding antagonist of beta-catenin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dact3provided by RGD
Official Full Name: dishevelled-binding antagonist of beta-catenin 3provided by RGD
Primary source: RGD:1563892
See related: Ensembl:ENSRNOG00000052256 AllianceGenome:RGD:1563892
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563892
Summary: Predicted to enable several functions, including delta-catenin binding activity; identical protein binding activity; and protein kinase C binding activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of cell growth. Predicted to act upstream of or within negative regulation of epithelial to mesenchymal transition. Predicted to be active in cytoplasm. Orthologous to human DACT3 (dishevelled binding antagonist of beta catenin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 185.5), Uterus (RPKM 59.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (86674989..86686722)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (77546900..77558631)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (78800754..78812483)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA965116 (e-PCR)
- UniSTS:248623

UniSTS:498291 (e-PCR)
- UniSTS:498291

Dact3 (e-PCR), detects polymorphism
- UniSTS:498291

RH143844 (e-PCR)
- UniSTS:233090

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables delta-catenin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dapper homolog 3

Names: dapper, antagonist of beta-catenin, homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191947.2 → NP_001178876.2 dapper homolog 3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5YBM3, M0R4J7

Related

ENSRNOP00000075172.1, ENSRNOT00000084601.2

Conserved Domains (1) summary

pfam15268
Location:20 → 610

Dapper

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

86674989..86686722

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087026.2 → XP_038942954.1 dapper homolog 3 isoform X1

UniProtKB/TrEMBL

A0A8I5YBM3

Conserved Domains (1) summary

pfam15268
Location:20 → 610

Dapper