Zbtb42 zinc finger and BTB domain containing 42 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zbtb42provided by RGD
Official Full Name: zinc finger and BTB domain containing 42provided by RGD
Primary source: RGD:1582758
See related: Ensembl:ENSRNOG00000037562 AllianceGenome:RGD:1582758
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in muscle organ development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ZBTB42 (zinc finger and BTB domain containing 42). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 28.0), Heart (RPKM 22.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (137559622..137561750)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (131734257..131742459)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (137238899..137247115)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in muscle organ development	ISO Inferred from Sequence Orthology more info
involved_in muscle organ development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126302.1 → NP_001119774.1 zinc finger and BTB domain-containing protein 42

See identical proteins and their annotated locations for NP_001119774.1

Status: PROVISIONAL

Source sequence(s)

BC161864

UniProtKB/Swiss-Prot

B1WBS3

Related

ENSRNOP00000035859.4, ENSRNOT00000030879.5

Conserved Domains (4) summary

COG5048
Location:334 → 388

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:334 → 354

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18956
Location:1 → 129

BTB_POZ_ZBTB42; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42)

pfam13465
Location:347 → 369

zf-H2C2_2; Zinc-finger double domain