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    Amz2 archaelysin family metallopeptidase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360650, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Amz2provided by RGD
    Official Full Name
    archaelysin family metallopeptidase 2provided by RGD
    Primary source
    RGD:1304846
    See related
    Ensembl:ENSRNOG00000000246 AllianceGenome:RGD:1304846
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304846
    Summary
    Predicted to enable metal ion binding activity and metallopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human AMZ2 (archaelysin family metallopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 144.2), Testes (RPKM 133.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Amz2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (94901053..94911629)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (94401546..94412116)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (97710905..97721442)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480892 Neighboring gene G protein subunit alpha 13 Neighboring gene arylsulfatase G Neighboring gene solute carrier family 16, member 6 Neighboring gene 5E5 antigen-like Neighboring gene WD repeat domain, phosphoinositide interacting 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    archaemetzincin-2
    Names
    archeobacterial metalloproteinase-like 2
    archeobacterial metalloproteinase-like protein 2
    NP_001014143.1
    XP_038942350.1
    XP_038942351.1
    XP_063125541.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014121.1 → NP_001014143.1  archaemetzincin-2

      See identical proteins and their annotated locations for NP_001014143.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085886
      UniProtKB/Swiss-Prot
      Q400C7, Q5U2S2
      UniProtKB/TrEMBL
      A0A8L2UHB8
      Related
      ENSRNOP00000000263.6, ENSRNOT00000000263.7
      Conserved Domains (1) summary
      cd11375
      Location:88 → 298
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      94901053..94911629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086422.2 → XP_038942350.1  archaemetzincin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AHA7, A0A8L2UHB8
      Related
      ENSRNOP00000094228.1
      Conserved Domains (1) summary
      cd11375
      Location:88 → 298
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

    2. XM_063269471.1 → XP_063125541.1  archaemetzincin-2 isoform X2

    3. XM_039086423.1 → XP_038942351.1  archaemetzincin-2 isoform X3

      Conserved Domains (1) summary
      cd11375
      Location:69 → 264
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q400C7.2 GenPept UniProtKB/Swiss-Prot:Q400C7

    Gene LinkOut

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