Adam19 ADAM metallopeptidase domain 19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adam19provided by RGD
Official Full Name: ADAM metallopeptidase domain 19provided by RGD
Primary source: RGD:1585017
See related: Ensembl:ENSRNOG00000042980 AllianceGenome:RGD:1585017
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sox30
Summary: Predicted to enable SH3 domain binding activity and metalloendopeptidase activity involved in amyloid precursor protein catabolic process. Predicted to be involved in several processes, including amyloid precursor protein catabolic process; positive regulation of cell-cell adhesion mediated by cadherin; and proteolysis. Predicted to act upstream of or within heart development. Predicted to be located in Golgi apparatus and nucleus. Orthologous to human ADAM19 (ADAM metallopeptidase domain 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 306.1), Thymus (RPKM 156.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q21

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (30992713..31084455)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (30491362..30583115)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (31146107..31240582)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TGF-beta stimulation of renal cells results in a significant up-regulation of Adams 10, 17, 12, and 19
Title: Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128156 (e-PCR)
- UniSTS:211464

D10Got50 (e-PCR)
- UniSTS:115510

AU049292 (e-PCR)
- UniSTS:145740

AI431060 (e-PCR)
- UniSTS:160087

BF410193 (e-PCR)
- UniSTS:246719

RH128894 (e-PCR)
- UniSTS:212202

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in placenta development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
NOT located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 19

Names: SRY-box containing gene 30; a disintegrin and metallopeptidase domain 19 (meltrin beta); a disintegrin and metalloproteinase domain 19 (meltrin beta); meltrin beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001160228.1 → NP_001153700.1 disintegrin and metalloproteinase domain-containing protein 19 precursor

See identical proteins and their annotated locations for NP_001153700.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5Y236, A6HDQ9, D3ZPM7

Related

ENSRNOP00000077829.1, ENSRNOT00000108861.1

Conserved Domains (5) summary

smart00050
Location:440 → 500

DISIN; Homologues of snake disintegrins

smart00608
Location:502 → 650

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:211 → 407

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:211 → 409

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:62 → 162

Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

30992713..31084455

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268971.1 → XP_063125041.1 disintegrin and metalloproteinase domain-containing protein 19 isoform X2
XM_039085916.2 → XP_038941844.1 disintegrin and metalloproteinase domain-containing protein 19 isoform X3

Conserved Domains (3) summary

pfam01421
Location:211 → 409

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:45 → 163

Pep_M12B_propep; Reprolysin family propeptide

cl10507
Location:440 → 460

Disintegrin
XM_039085915.2 → XP_038941843.1 disintegrin and metalloproteinase domain-containing protein 19 isoform X1

UniProtKB/TrEMBL

D3ZPM7

Conserved Domains (4) summary

smart00050
Location:386 → 446

DISIN; Homologues of snake disintegrins

smart00608
Location:448 → 596

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:157 → 355

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:15 → 109

Pep_M12B_propep; Reprolysin family propeptide
XM_039085917.2 → XP_038941845.1 disintegrin and metalloproteinase domain-containing protein 19 isoform X4

Conserved Domains (2) summary

smart00608
Location:34 → 182

ACR; ADAM Cysteine-Rich Domain

cl10507
Location:1 → 32

Disintegrin