Camk2d calcium/calmodulin-dependent protein kinase II delta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Camk2dprovided by RGD
Official Full Name: calcium/calmodulin-dependent protein kinase II deltaprovided by RGD
Primary source: RGD:2263
See related: Ensembl:ENSRNOG00000011589 AllianceGenome:RGD:2263
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CAMK1; Camk2; Camki; RATCAMKI
Summary: Enables calmodulin-dependent protein kinase activity; nitric-oxide synthase binding activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; protein phosphorylation; and regulation of calcium ion transmembrane transport. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study epilepsy. Orthologous to human CAMK2D (calcium/calmodulin dependent protein kinase II delta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 281.6), Brain (RPKM 235.3) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 2q42

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (217698324..217961898)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (215023785..215287351)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (230900907..231132207)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Consumption of combined fructose and sucrose diet exacerbates oxidative stress, hypertrophy and CaMKIIdelta oxidation in hearts from rats with metabolic syndrome.
Title: Consumption of combined fructose and sucrose diet exacerbates oxidative stress, hypertrophy and CaMKII(δ) oxidation in hearts from rats with metabolic syndrome.
AKAP18delta Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR.
Title: AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR.
CaMKII exacerbates heart failure progression by activating class I HDACs.
Title: CaMKII exacerbates heart failure progression by activating class I HDACs.
Sphingosine kinase 1 regulates HMGB1 translocation by directly interacting with calcium/calmodulin protein kinase II-delta in sepsis-associated liver injury.
Title: Sphingosine kinase 1 regulates HMGB1 translocation by directly interacting with calcium/calmodulin protein kinase II-δ in sepsis-associated liver injury.
The combined inhibition of the CaMKIIdelta and calcineurin signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
Title: The combined inhibition of the CaMKIIδ and calcineurin signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
CaMKIIdelta expression is significantly increased and activated in the endothelium of aged aorta, and could serve as an important marker of endothelial dysfunction that accompanies the ageing process.
Title: Compromised cardiovascular function in aged rats corresponds with increased expression and activity of calcium/calmodulin dependent protein kinase IIδ in aortic endothelium.
Kv4.3 reduction is an important mediator in cardiac hypertrophy development via excessive CaMKII activation.
Title: Kv4.3 expression abrogates and reverses norepinephrine-induced myocyte hypertrophy by CaMKII inhibition.
In vitro, overexpression of miR-30c or miR-30e inhibited CaMKIIdelta2 protein expression by ~50% in cultured rat aortic vascular smooth muscle cells, and inhibited vascular smooth muscle cell proliferation and migration.
Title: MicroRNA-30 inhibits neointimal hyperplasia by targeting Ca(2+)/calmodulin-dependent protein kinase IIδ (CaMKIIδ).
up-regulation of CaMKIIdelta may contribute to the phenylephrine-induced myocardial hypertrophy through the activation of store-operated Ca2+ entry expressed in the cardiomyocytes
Title: CaMKIIδ meditates phenylephrine induced cardiomyocyte hypertrophy through store-operated Ca(2+) entry.
ISO increased NOXs-derived ROS which activated nuclear translocation of calpain-2, subsequently nuclear calpain-2 degraded CaMK II dB which reduced the ratio of Bcl-2 to Bax and mitochondria apoptosis pathway was triggered in rat cardiomyocytes
Title: ROS-Induced Nuclear Translocation of Calpain-2 Facilitates Cardiomyocyte Apoptosis in Tail-Suspended Rats.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D2Wox40 (e-PCR)
- UniSTS:518952

D2Got192 (e-PCR)
- UniSTS:111659

RH144538 (e-PCR)
- UniSTS:233783

RH138932 (e-PCR)
- UniSTS:221018

RH133136 (e-PCR)
- UniSTS:216419

D2Mco44 (e-PCR)
- UniSTS:239460

D2Got155 (e-PCR)
- UniSTS:112527

RH94737 (e-PCR)
- UniSTS:119984

D2Got152 (e-PCR)
- UniSTS:115643

RH134058 (e-PCR)
- UniSTS:217340

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables sodium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables titin binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell contraction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular potassium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Rac protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle hypertrophy	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cardiac muscle cell action potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction	IC Inferred by Curator more info	PubMed
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IC Inferred by Curator more info	PubMed
involved_in regulation of cell communication by electrical coupling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell communication by electrical coupling involved in cardiac conduction	IC Inferred by Curator more info	PubMed
involved_in regulation of cellular localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of relaxation of cardiac muscle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of relaxation of cardiac muscle	ISO Inferred from Sequence Orthology more info
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in relaxation of cardiac muscle	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in axon initial segment	ISO Inferred from Sequence Orthology more info
part_of calcium- and calmodulin-dependent protein kinase complex	ISO Inferred from Sequence Orthology more info
is_active_in cochlear hair cell ribbon synapse	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in organelle	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: calcium/calmodulin-dependent protein kinase type II subunit delta

Names: Ca++/calmodulin-dependent protein kinase 2 delta subunit; Ca++/calmodulin-dependent protein kinase II, delta subunit; caM kinase II subunit delta; caM-kinase II delta chain; caMK-II subunit delta; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase type II delta chain

NP_036651.1

EC 2.7.11.17

XP_006233347.2

EC 2.7.11.17

XP_008759674.1

EC 2.7.11.17

XP_017446093.1

EC 2.7.11.17

XP_017446094.1

EC 2.7.11.17

XP_017446096.1

EC 2.7.11.17

XP_017446097.1

EC 2.7.11.17

XP_017446099.1

EC 2.7.11.17

XP_017446101.1

EC 2.7.11.17

XP_017446102.1

EC 2.7.11.17

XP_017446103.1

EC 2.7.11.17

XP_017446105.1

EC 2.7.11.17

XP_017446107.1

EC 2.7.11.17

XP_038957614.1

EC 2.7.11.17

XP_038957616.1

EC 2.7.11.17

XP_038957617.1

EC 2.7.11.17

XP_038957618.1

EC 2.7.11.17

XP_038957621.1

EC 2.7.11.17

XP_038957622.1

EC 2.7.11.17

XP_038957624.1

EC 2.7.11.17

XP_038957631.1

EC 2.7.11.17

XP_038957632.1

EC 2.7.11.17

XP_063137349.1

EC 2.7.11.17

XP_063137351.1

EC 2.7.11.17

XP_063137352.1

EC 2.7.11.17

XP_063137353.1

EC 2.7.11.17

XP_063137354.1

EC 2.7.11.17

XP_063137355.1

EC 2.7.11.17

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012519.2 → NP_036651.1 calcium/calmodulin-dependent protein kinase type II subunit delta

See identical proteins and their annotated locations for NP_036651.1

Status: PROVISIONAL

Source sequence(s)

J05072

UniProtKB/Swiss-Prot

P15791, P97915, P97916, Q3B7L0, Q63904, Q63905, Q63906, Q63907, Q63908

UniProtKB/TrEMBL

A0A8L2QW89, A6HVK9

Related

ENSRNOP00000016026.6, ENSRNOT00000016026.9

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:380 → 507

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

217698324..217961898

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233285.5 → XP_006233347.2 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X14

UniProtKB/TrEMBL

A0A8I6A1N4

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:357 → 484

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_017590604.3 → XP_017446093.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2

UniProtKB/Swiss-Prot

P15791, P97915, P97916, Q3B7L0, Q63904, Q63905, Q63906, Q63907, Q63908

UniProtKB/TrEMBL

A0A8L2QW89, A6HVK9

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:380 → 507

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_017590613.3 → XP_017446102.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X10

UniProtKB/TrEMBL

A0A8I6AT87

Related

ENSRNOP00000095840.1
XM_017590610.3 → XP_017446099.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X6

UniProtKB/TrEMBL

A0A8I6AT87
XM_039101696.2 → XP_038957624.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X19

UniProtKB/TrEMBL

A0A8I6AT87

Related

ENSRNOP00000097734.1

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:366 → 493

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_017590612.3 → XP_017446101.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X8

UniProtKB/TrEMBL

A0A8I6AL07

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:360 → 487

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_063281282.1 → XP_063137352.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X17
XM_039101703.2 → XP_038957631.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X23

UniProtKB/TrEMBL

A0A8I6A1N4, A6HVK8

Related

ENSRNOP00000015559.7

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:346 → 473

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_017590616.3 → XP_017446105.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X16

UniProtKB/TrEMBL

A0A8I6A1N4
XM_017590607.3 → XP_017446096.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3

UniProtKB/TrEMBL

A0A8L2QW89
XM_039101686.2 → XP_038957614.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X7

UniProtKB/TrEMBL

A0A8I6AT87

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:365 → 492

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_039101689.2 → XP_038957617.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X12

UniProtKB/TrEMBL

A0A8I6AL07

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:359 → 486

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_017590618.3 → XP_017446107.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X20

UniProtKB/TrEMBL

A0A8I6A1N4

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:345 → 472

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_039101704.2 → XP_038957632.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X24

UniProtKB/TrEMBL

A0A8I6A1N4

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:345 → 472

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_017590614.3 → XP_017446103.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X15

UniProtKB/TrEMBL

A0A8I6A1N4
XM_008761452.3 → XP_008759674.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1

UniProtKB/TrEMBL

A0A8L2QW89

Related

ENSRNOP00000085967.1

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:380 → 507

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_063281281.1 → XP_063137351.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X11

UniProtKB/TrEMBL

A0A8I6A550
XM_063281279.1 → XP_063137349.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X5
XM_063281283.1 → XP_063137353.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X21
XM_039101688.2 → XP_038957616.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X9

UniProtKB/TrEMBL

A0A8I6AL07

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:360 → 487

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_039101694.2 → XP_038957622.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X18

UniProtKB/TrEMBL

A0A8I6A1N4

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:346 → 473

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_017590608.3 → XP_017446097.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4

UniProtKB/TrEMBL

A0A8L2QW89
XM_039101690.2 → XP_038957618.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X13

UniProtKB/TrEMBL

A0A8I6AL07

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:359 → 486

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_063281284.1 → XP_063137354.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X22
XM_017590605.3 → XP_017446094.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2

UniProtKB/Swiss-Prot

P15791, P97915, P97916, Q3B7L0, Q63904, Q63905, Q63906, Q63907, Q63908

UniProtKB/TrEMBL

A0A8L2QW89, A6HVK9

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:380 → 507

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_039101693.2 → XP_038957621.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X17

UniProtKB/TrEMBL

A0A8I6A1N4

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:346 → 473

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_063281285.1 → XP_063137355.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform X25