Cdk17 cyclin-dependent kinase 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdk17provided by RGD
Official Full Name: cyclin-dependent kinase 17provided by RGD
Primary source: RGD:1565593
See related: Ensembl:ENSRNOG00000004148 AllianceGenome:RGD:1565593
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pctk2; Pctaire2
Summary: Predicted to enable ATP binding activity; cyclin-dependent protein serine/threonine kinase activity; and protein serine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDK17 (cyclin dependent kinase 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 189.0), Lung (RPKM 151.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (29570982..29677613)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (27683890..27765814)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (34001506..34088418)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH143587 (e-PCR)
- UniSTS:232833

AA859024 (e-PCR)
- UniSTS:243858

BE116510 (e-PCR)
- UniSTS:248498

RH138280 (e-PCR)
- UniSTS:220367

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclin-dependent kinase 17

Names: PCTAIRE protein kinase 2; PCTAIRE-motif protein kinase 2; cell division protein kinase 17; serine/threonine-protein kinase PCTAIRE-2

NP_001101552.2

EC 2.7.11.22

XP_006241315.1

EC 2.7.11.22

XP_017450324.2

EC 2.7.11.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108082.2 → NP_001101552.2 cyclin-dependent kinase 17

See identical proteins and their annotated locations for NP_001101552.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

O35831

UniProtKB/TrEMBL

A6IFX6, G3V6J5

Related

ENSRNOP00000005762.4, ENSRNOT00000005762.5

Conserved Domains (1) summary

cd07872
Location:185 → 493

STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

29570982..29677613

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241253.5 → XP_006241315.1 cyclin-dependent kinase 17 isoform X2

UniProtKB/Swiss-Prot

O35831

Conserved Domains (2) summary

cd07872
Location:201 → 509

STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

PLN00009
Location:205 → 493

PLN00009; cyclin-dependent kinase A; Provisional
XM_017594835.3 → XP_017450324.2 cyclin-dependent kinase 17 isoform X1

UniProtKB/Swiss-Prot

O35831

UniProtKB/TrEMBL

A6IFX5