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    Psma4 proteasome 20S subunit alpha 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29671, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Psma4provided by RGD
    Official Full Name
    proteasome 20S subunit alpha 4provided by RGD
    Primary source
    RGD:61846
    See related
    Ensembl:ENSRNOG00000013493 AllianceGenome:RGD:61846
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable threonine-type endopeptidase activity. Predicted to be involved in proteasomal protein catabolic process. Predicted to be located in P-body and nucleoplasm. Predicted to be part of proteasome core complex, alpha-subunit complex. Predicted to be active in cytosol and nucleus. Orthologous to human PSMA4 (proteasome 20S subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 746.9), Adrenal (RPKM 705.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psma4 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (64236520..64243980)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (55340431..55347893)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (59532456..59539916)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene iron responsive element binding protein 2 Neighboring gene hydroxylysine kinase Neighboring gene cholinergic receptor nicotinic alpha 5 subunit Neighboring gene zinc finger CCCH-type containing 15, pseudogene 2 Neighboring gene uncharacterized LOC120094166 Neighboring gene cholinergic receptor nicotinic alpha 3 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and sequencing of component C9 of proteasomes from rat hepatoma cells. Kumatori A, et al. FEBS Lett, 1990 May 21. PMID 2358075
    2. Molecular cloning of cDNAs for two subunits of rat multicatalytic proteinase. Existence of N-terminal conserved and C-terminal diverged sequences among subunits. Sorimachi H, et al. Eur J Biochem, 1990 Nov 13. PMID 2249692
    3. Parkin interacts with the proteasome subunit alpha4. Dächsel JC, et al. FEBS Lett, 2005 Jul 18. PMID 15987638
    4. PAC1-PAC2 proteasome assembly chaperone retains the core α4-α7 assembly intermediates in the cytoplasm. Wu W, et al. Genes Cells, 2018 Oct. PMID 30133132
    5. A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1. Moscovitz O, et al. Mol Cell, 2012 Jul 13. PMID 22793692

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Parkin interacts with the proteasome subunit alpha4
      Title: Parkin interacts with the proteasome subunit alpha4.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome subunit alpha type-4
    Names
    macropain subunit C9
    multicatalytic endopeptidase complex subunit C9
    multicatalytic proteinase subunit L
    proteasome (prosome, macropain) subunit, alpha type 4
    proteasome alpha 4 subunit
    proteasome component C9
    proteasome subunit L
    proteasome subunit alpha 4
    NP_058977.1
    XP_038936898.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017281.1 → NP_058977.1  proteasome subunit alpha type-4

      See identical proteins and their annotated locations for NP_058977.1

      Status: PROVISIONAL

      Source sequence(s)
      X53304
      UniProtKB/Swiss-Prot
      P21670
      UniProtKB/TrEMBL
      A6J4N4, Q6P505
      Related
      ENSRNOP00000018173.5, ENSRNOT00000018173.7
      Conserved Domains (1) summary
      cd03752
      Location:3 → 216
      proteasome_alpha_type_4; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      64236520..64243980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080970.2 → XP_038936898.1  proteasome subunit alpha type-4 isoform X1

      UniProtKB/Swiss-Prot
      P21670
      UniProtKB/TrEMBL
      A6J4N4, Q6P505
      Conserved Domains (1) summary
      cd03752
      Location:3 → 216
      proteasome_alpha_type_4; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21670.1 GenPept UniProtKB/Swiss-Prot:P21670

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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