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    Ggt7 gamma-glutamyltransferase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 156275, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ggt7provided by RGD
    Official Full Name
    gamma-glutamyltransferase 7provided by RGD
    Primary source
    RGD:619870
    See related
    Ensembl:ENSRNOG00000018441 AllianceGenome:RGD:619870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ggtl3
    Summary
    Predicted to enable glutathione hydrolase activity and peptidyltransferase activity. Predicted to be involved in several processes, including glutathione catabolic process; response to estradiol; and response to tumor necrosis factor. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human GGT7 (gamma-glutamyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 72.4), Thymus (RPKM 8.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ggt7 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164438240..164464059, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (143978073..144004597, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (151005960..151029941, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 6 Neighboring gene U1 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA18 Neighboring gene acyl-CoA synthetase short-chain family member 2 Neighboring gene glutathione synthetase Neighboring gene myosin heavy chain 7B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a novel gamma-glutamyl transpeptidase homologue found in rat brain. Yamaguchi T, et al. J Biochem, 2000 Jul. PMID 10876163
    2. γ-Glutamyl transferase 7 is a novel regulator of glioblastoma growth. Bui TT, et al. BMC Cancer, 2015 Apr 7. PMID 25884624, Free PMC Article
    3. Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism. He X, et al. Biochem Biophys Res Commun, 2002 Sep 27. PMID 12270127
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene C4 gamma-glutamyl transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutathione hydrolase 7
    Names
    GGT 7
    gamma-glutamyltransferase-like 3
    gamma-glutamyltranspeptidase 7
    NP_569107.2
    XP_008760522.1
    XP_038960082.1
    XP_038960083.1
    XP_038960084.1
    XP_038960085.1
    XP_038960086.1
    XP_038960087.1
    XP_038960088.1
    XP_038960090.1
    XP_063139093.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130423.2 → NP_569107.2  glutathione hydrolase 7

      See identical proteins and their annotated locations for NP_569107.2

      Status: VALIDATED

      Source sequence(s)
      AA925130, AF244973, CB761916
      UniProtKB/Swiss-Prot
      Q99MZ4
      UniProtKB/TrEMBL
      A6KI39, A6KI40
      Related
      ENSRNOP00000025315.3, ENSRNOT00000025315.6
      Conserved Domains (1) summary
      pfam01019
      Location:155 → 653
      G_glu_transpept; Gamma-glutamyltranspeptidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      164438240..164464059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104160.2 → XP_038960088.1  glutathione hydrolase 7 isoform X9

      UniProtKB/TrEMBL
      A6KI39
      Conserved Domains (1) summary
      pfam01019
      Location:79 → 589
      G_glu_transpept; Gamma-glutamyltranspeptidase

    2. XM_039104156.2 → XP_038960084.1  glutathione hydrolase 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A1D7, A6KI39
      Related
      ENSRNOP00000085996.1
      Conserved Domains (1) summary
      pfam01019
      Location:155 → 660
      G_glu_transpept; Gamma-glutamyltranspeptidase

    3. XM_039104154.2 → XP_038960082.1  glutathione hydrolase 7 isoform X1

      UniProtKB/TrEMBL
      A6KI39
      Conserved Domains (1) summary
      pfam01019
      Location:155 → 665
      G_glu_transpept; Gamma-glutamyltranspeptidase

    4. XM_039104158.2 → XP_038960086.1  glutathione hydrolase 7 isoform X6

      UniProtKB/Swiss-Prot
      Q99MZ4
      UniProtKB/TrEMBL
      A6KI39, A6KI40
      Conserved Domains (1) summary
      pfam01019
      Location:155 → 653
      G_glu_transpept; Gamma-glutamyltranspeptidase

    5. XM_008762300.4 → XP_008760522.1  glutathione hydrolase 7 isoform X4

      UniProtKB/TrEMBL
      A6KI39
      Conserved Domains (1) summary
      pfam01019
      Location:155 → 658
      G_glu_transpept; Gamma-glutamyltranspeptidase

    6. XM_039104157.2 → XP_038960085.1  glutathione hydrolase 7 isoform X5

      UniProtKB/TrEMBL
      A6KI39
      Conserved Domains (1) summary
      pfam01019
      Location:155 → 657
      G_glu_transpept; Gamma-glutamyltranspeptidase

    7. XM_039104155.2 → XP_038960083.1  glutathione hydrolase 7 isoform X2

      UniProtKB/TrEMBL
      A6KI39
      Conserved Domains (1) summary
      pfam01019
      Location:155 → 662
      G_glu_transpept; Gamma-glutamyltranspeptidase

    8. XM_063283023.1 → XP_063139093.1  glutathione hydrolase 7 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZYT2

    9. XM_039104159.2 → XP_038960087.1  glutathione hydrolase 7 isoform X7

      UniProtKB/TrEMBL
      A6KI39
      Conserved Domains (1) summary
      pfam01019
      Location:100 → 610
      G_glu_transpept; Gamma-glutamyltranspeptidase

    10. XM_039104162.2 → XP_038960090.1  glutathione hydrolase 7 isoform X10

      Conserved Domains (1) summary
      cl19223
      Location:1 → 424
      G_glu_transpept; Gamma-glutamyltranspeptidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MZ4.2 GenPept UniProtKB/Swiss-Prot:Q99MZ4

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