Uts2 urotensin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uts2provided by RGD
Official Full Name: urotensin 2provided by RGD
Primary source: RGD:3930
See related: Ensembl:ENSRNOG00000018393 AllianceGenome:RGD:3930
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: UII; U-II; Ucn2
Summary: Predicted to enable hormone activity. Involved in several processes, including negative regulation of secretion; regulation of blood pressure; and regulation of heart rate. Located in extracellular space. Used to study hypertension. Biomarker of asthma; cardiomyopathy; endomyocardial fibrosis; myocardial infarction; and pulmonary hypertension. Human ortholog(s) of this gene implicated in gestational diabetes and type 2 diabetes mellitus. Orthologous to human UTS2 (urotensin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 4.7), Testes (RPKM 1.8) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (166725471..166739063)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (161450846..161456235)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (168078748..168084133)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There is an increase of Ucn2 mRNA levels in the adrenal medulla and spleen induced by immobilization stress.
Title: Stressors affect urocortin 1 and urocortin 2 gene expression in rat spleen: The role of glucocorticoids.
Aldosterone and its receptors were expressed on tunica adventitia. Urotensin II promoted ALD protein secretion from cells in a dose and timedependent manner.
Title: Urotensin II promotes aldosterone expression in rat aortic adventitial fibroblasts.
These results suggest that urotensin II induces cardiomyocyte hypertrophy through the cAMP-dependent protein kinase A -mediated upregulation of phospholamban phosphorylation at Ser16, which provides a new experimental foundation for the prevention and/or treatment of cardiac hypertrophy.
Title: Role of PKA in the process of neonatal cardiomyocyte hypertrophy induced by urotensin II.
IRF3 expression and activation depend on the signal transduction of the the urotensin II/urotensin receptor (UII/UT) system, and play important roles in UII/UT-mediated immune inflammatory injury in the liver
Title: IRF3 is an important molecule in the UII/UT system and mediates immune inflammatory injury in acute liver failure.
This study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation
Title: Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats.
results suggest that GRK5 may be involved in a UII-mediated hypertrophic response via activation of NF-kappaB and HDAC5 at least in part by ERK1/2 and GSK3alpha/beta-independent pathways.
Title: A novel role of G protein-coupled receptor kinase 5 in urotensin II-stimulated cellular hypertrophy in H9c2(UT) cells.
This study investigates the role and mode of action of urotensin II (U II) in the occurrence and progression of cardiac fibrosis in a pressureoverload rat model.
Title: An investigation into the expression and mechanism of action of urotensin II in chronic pressure-overloaded rat hearts.
Urotensin II expression was increased significantly in brain from focal cerebral ischemia animals.
Title: Expression of Urotensin II During Focal Cerebral Ischemic in Diabetic Rats.
The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-kappaB pathways in LPS-stimulated Kupffer cells.
Title: The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-κB pathways in LPS-stimulated Kupffer cells.
MDA-MB-231 displayed a statistically significant higher sigma-2 receptor expression and also was the most sensitive cell line evaluated to SW IV-134
Title: The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (43)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood vessel diameter maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glomerular filtration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of heart rate	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of urine volume	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, REM sleep	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, wakefulness	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of collagen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of heart rate	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, cholinergic	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: urotensin-2

Names: urocortin 2; urotensin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.