Ubl5 ubiquitin-like 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ubl5provided by RGD
Official Full Name: ubiquitin-like 5provided by RGD
Primary source: RGD:1564644
See related: AllianceGenome:RGD:1564644
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: beacon
Summary: Predicted to enable protein tag. Predicted to be involved in cellular protein modification process; mRNA splicing, via spliceosome; and positive regulation of protein targeting to mitochondrion. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBL5 (ubiquitin like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 460.7), Thymus (RPKM 426.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (27457738..27461458)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (19181504..19185224)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (21663257..21665049)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The topographical distribution of beacon immunoreactivity in rat brain indicates its possible function as a neutrotransmitter, a neuromodulator, or a neuroendocrine regulator, depending upon its localization.
Title: Distribution of beacon immunoreactivity in the rat brain.
The hypothesis is advanced that beacon is to be considered an autocrine-paracrine negative regulator of mineralo- and glucocorticoid synthesis in the rat adrenal gland.
Title: Differential expression and function of beacon in the rat adrenal cortex and medulla.
a hypothalamic peptide involved in the regulation of food intake which might act as an endogenous inhibitor of adrenocortical growth in the rat.
Title: Down-regulation of the beacon gene expression in the regenerating rat adrenal cortex.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein modification process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein modification process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin-like protein 5

Names: ubiquitin-like 5 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048243.3 → NP_001041708.2 ubiquitin-like protein 5

See identical proteins and their annotated locations for NP_001041708.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A9UMW0

Conserved Domains (1) summary

cd01791
Location:1 → 71

Ubl_UBL5; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins
NM_001393882.1 → NP_001380811.1 ubiquitin-like protein 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A9UMW0

Conserved Domains (1) summary

cd01791
Location:1 → 71

Ubl_UBL5; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins
NM_001393883.1 → NP_001380812.1 ubiquitin-like protein 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A9UMW0

Conserved Domains (1) summary

cd01791
Location:1 → 71

Ubl_UBL5; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins