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    Lpcat4 lysophosphatidylcholine acyltransferase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296048, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Lpcat4provided by RGD
    Official Full Name
    lysophosphatidylcholine acyltransferase 4provided by RGD
    Primary source
    RGD:1311177
    See related
    Ensembl:ENSRNOG00000005058 AllianceGenome:RGD:1311177
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Agpat7; RGD1311177
    Summary
    Predicted to enable O-acyltransferase activity and lysophospholipid acyltransferase activity. Predicted to be involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Predicted to act upstream of or within phospholipid metabolic process. Predicted to be located in endoplasmic reticulum. Orthologous to human LPCAT4 (lysophosphatidylcholine acyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 66.1), Kidney (RPKM 25.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lpcat4 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (119499128..119507275)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (99044729..99052963)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (103725762..103733888)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cleavage stimulation factor subunit 3, pseudogene 1 Neighboring gene PRELI domain containing 1, pseudogene 1 Neighboring gene NUT midline carcinoma, family member 1 Neighboring gene NOP10 ribonucleoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2. Cao J, et al. J Biol Chem, 2008 Jul 4. PMID 18458083
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerophosphocholine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-acylglycerophosphoethanolamine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-acylglycerophosphoserine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-alkenylglycerophosphoethanolamine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-alkylglycerophosphocholine O-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophospholipid acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylcholine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylethanolamine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylserine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysophospholipid acyltransferase LPCAT4
    Names
    1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)
    NP_001099964.1
    XP_063139384.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106494.1 → NP_001099964.1  lysophospholipid acyltransferase LPCAT4

      See identical proteins and their annotated locations for NP_001099964.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A6HP43, D3ZR52
      Related
      ENSRNOP00000006776.7, ENSRNOT00000006776.8
      Conserved Domains (2) summary
      cd07991
      Location:109 → 306
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:109 → 295
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      119499128..119507275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283314.1 → XP_063139384.1  lysophospholipid acyltransferase LPCAT4 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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