Srp54a signal recognition particle 54A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srp54aprovided by RGD
Official Full Name: signal recognition particle 54Aprovided by RGD
Primary source: RGD:621390
See related: Ensembl:ENSRNOG00000032776 AllianceGenome:RGD:621390
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Srp54
Summary: Predicted to enable several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Predicted to contribute to GTPase activity. Predicted to be involved in several processes, including SRP-dependent cotranslational protein targeting to membrane; exocrine pancreas development; and neutrophil chemotaxis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 181.5), Adrenal (RPKM 152.2) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6q23

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (78322308..78362017)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (72587584..72626878)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (75996629..76035768)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128735 (e-PCR)
- UniSTS:212043

AU025106 (e-PCR)
- UniSTS:115591

D6Rat22 (e-PCR)
- UniSTS:118961

RH144431 (e-PCR)
- UniSTS:233676

fd49c07.y1 (e-PCR)
- UniSTS:195554

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 7S RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables 7S RNA binding	IEA Inferred from Electronic Annotation more info
enables 7S RNA binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
contributes_to GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
contributes_to GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables endoplasmic reticulum signal peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables endoplasmic reticulum signal peptide binding	ISO Inferred from Sequence Orthology more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition	ISO Inferred from Sequence Orthology more info
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in exocrine pancreas development	ISS Inferred from Sequence or Structural Similarity more info
involved_in granulocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in granulocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to ER	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of signal recognition particle, endoplasmic reticulum targeting	IBA Inferred from Biological aspect of Ancestor more info
part_of signal recognition particle, endoplasmic reticulum targeting	IEA Inferred from Electronic Annotation more info
part_of signal recognition particle, endoplasmic reticulum targeting	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal recognition particle subunit SRP54

Names: signal recognition particle 54 kDa protein

NP_446323.1

EC 3.6.5.4

XP_006240159.1

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053871.1 → NP_446323.1 signal recognition particle subunit SRP54

See identical proteins and their annotated locations for NP_446323.1

Status: PROVISIONAL

Source sequence(s)

BC079117

UniProtKB/Swiss-Prot

Q6AYB5

UniProtKB/TrEMBL

A0A8I6A4J0

Related

ENSRNOP00000085749.1, ENSRNOT00000098782.1

Conserved Domains (1) summary

TIGR01425
Location:2 → 430

SRP54_euk; signal recognition particle protein SRP54

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

78322308..78362017

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240097.5 → XP_006240159.1 signal recognition particle subunit SRP54 isoform X1

UniProtKB/TrEMBL

A0A8I6A4J0

Conserved Domains (4) summary

COG0541
Location:2 → 440

Ffh; Signal recognition particle GTPase [Intracellular trafficking, secretion, and vesicular transport]

pfam00448
Location:102 → 294

SRP54; SRP54-type protein, GTPase domain

pfam02881
Location:6 → 83

SRP54_N; SRP54-type protein, helical bundle domain

pfam02978
Location:326 → 385

SRP_SPB; Signal peptide binding domain