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    Chst1 carbohydrate sulfotransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295934, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Chst1provided by RGD
    Official Full Name
    carbohydrate sulfotransferase 1provided by RGD
    Primary source
    RGD:1308142
    See related
    Ensembl:ENSRNOG00000007989 AllianceGenome:RGD:1308142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable N-acetylglucosamine 6-O-sulfotransferase activity and keratan sulfotransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process; galactose metabolic process; and keratan sulfate metabolic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in trans-Golgi network. Orthologous to human CHST1 (carbohydrate sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 104.7), Spleen (RPKM 75.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chst1 in Genome Data Viewer
    Location:
    3q31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (99003987..99030214)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (78552059..78574740)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (81441785..81512829)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486125 Neighboring gene uncharacterized LOC134486124 Neighboring gene uncharacterized LOC134486126 Neighboring gene uncharacterized LOC120101598 Neighboring gene uncharacterized LOC134486406 Neighboring gene uncharacterized LOC134486407

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase. Fukuta M, et al. J Biol Chem, 1997 Dec 19. PMID 9405439
    2. Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin. Bistrup A, et al. J Cell Biol, 1999 May 17. PMID 10330415, Free PMC Article
    3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables keratan sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables keratan sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables keratan sulfotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in keratan sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratan sulfate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in keratan sulfate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratan sulfate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfur compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbohydrate sulfotransferase 1
    Names
    GST-1
    KS6ST
    KSGal6ST
    KSST
    carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
    galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1
    keratan sulfate Gal-6 sulfotransferase
    NP_001011955.1
    XP_017447049.1
    XP_017447051.1
    XP_063139367.1
    XP_063139368.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011955.2 → NP_001011955.1  carbohydrate sulfotransferase 1

      See identical proteins and their annotated locations for NP_001011955.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q5RJQ0
      UniProtKB/TrEMBL
      A6HNH9
      Related
      ENSRNOP00000086161.1, ENSRNOT00000114058.1
      Conserved Domains (1) summary
      pfam00685
      Location:200 → 384
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      99003987..99030214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283298.1 → XP_063139368.1  carbohydrate sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5RJQ0
      UniProtKB/TrEMBL
      A6HNH9

    2. XM_017591562.3 → XP_017447051.1  carbohydrate sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5RJQ0
      UniProtKB/TrEMBL
      A6HNH9
      Related
      ENSRNOP00000090213.1
      Conserved Domains (1) summary
      pfam00685
      Location:200 → 384
      Sulfotransfer_1; Sulfotransferase domain

    3. XM_017591560.3 → XP_017447049.1  carbohydrate sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5RJQ0
      UniProtKB/TrEMBL
      A6HNH9
      Related
      ENSRNOP00000079857.1
      Conserved Domains (1) summary
      pfam00685
      Location:200 → 384
      Sulfotransfer_1; Sulfotransferase domain

    4. XM_063283297.1 → XP_063139367.1  carbohydrate sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5RJQ0
      UniProtKB/TrEMBL
      A6HNH9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RJQ0.1 GenPept UniProtKB/Swiss-Prot:Q5RJQ0

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