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    Iftap intraflagellar transport associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295952, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Iftapprovided by RGD
    Official Full Name
    intraflagellar transport associated proteinprovided by RGD
    Primary source
    RGD:1309730
    See related
    AllianceGenome:RGD:1309730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309730
    Summary
    Predicted to enable intraciliary transport particle A binding activity. Predicted to be involved in acrosome reaction and spermatogenesis. Predicted to act upstream of or within fertilization. Predicted to be active in 9+0 non-motile cilium and cytosol. Orthologous to human IFTAP (intraflagellar transport associated protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 126.3), Muscle (RPKM 118.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Iftap in Genome Data Viewer
    Location:
    3q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (108242105..108361607, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (87812068..87906517, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (91086186..91195981, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486296 Neighboring gene uncharacterized LOC103691849 Neighboring gene recombination activating 2 Neighboring gene recombination activating 1 Neighboring gene TNF receptor associated factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lack of NWC protein (c11orf74 homolog) in murine spermatogenesis results in reduced sperm competitiveness and impaired ability to fertilize egg cells in vitro. Majkowski M, et al. PLoS One, 2018. PMID 30521625, Free PMC Article
    2. Search for the Function of NWC, Third Gene Within RAG Locus: Generation and Characterization of NWC-Deficient Mice. Kasztura M, et al. Arch Immunol Ther Exp (Warsz), 2016 Aug. PMID 26703212, Free PMC Article
    3. C11ORF74 interacts with the IFT-A complex and participates in ciliary BBSome localization. Takahara M, et al. J Biochem, 2019 Mar 1. PMID 30476139
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables intraciliary transport particle A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intraciliary transport particle A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome reaction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acrosome reaction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+0 non-motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in 9+0 non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    intraflagellar transport-associated protein
    Names
    uncharacterized protein C11orf74 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106491.3 → NP_001099961.3  intraflagellar transport-associated protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNM0, B2RYT8

    2. NM_001429176.1 → NP_001416105.1  intraflagellar transport-associated protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNM0, B2RYT8

    3. NM_001429177.1 → NP_001416106.1  intraflagellar transport-associated protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      B2RYT8

    4. NM_001429178.1 → NP_001416107.1  intraflagellar transport-associated protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    5. NM_001429179.1 → NP_001416108.1  intraflagellar transport-associated protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      108242105..108361607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283301.1 → XP_063139371.1  intraflagellar transport-associated protein isoform X3

      UniProtKB/TrEMBL
      F1LQ29

    2. XM_063283300.1 → XP_063139370.1  intraflagellar transport-associated protein isoform X2

    3. XM_063283304.1 → XP_063139374.1  intraflagellar transport-associated protein isoform X6

    4. XM_063283305.1 → XP_063139375.1  intraflagellar transport-associated protein isoform X7

      UniProtKB/TrEMBL
      A6HNM1

    5. XM_063283299.1 → XP_063139369.1  intraflagellar transport-associated protein isoform X1

      UniProtKB/TrEMBL
      B2RYT8

    6. XM_063283302.1 → XP_063139372.1  intraflagellar transport-associated protein isoform X4

      UniProtKB/TrEMBL
      F1LQ29

    7. XM_063283303.1 → XP_063139373.1  intraflagellar transport-associated protein isoform X5

      UniProtKB/TrEMBL
      F1LQ29
    Nucleotide Protein Strain
    Heading Accession and Version

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