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    Stxbp6 syntaxin binding protein 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362734, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Stxbp6provided by RGD
    Official Full Name
    syntaxin binding protein 6provided by RGD
    Primary source
    RGD:1306117
    See related
    Ensembl:ENSRNOG00000004198 AllianceGenome:RGD:1306117
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Amisyn
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to be integral component of membrane. Predicted to be part of exocyst. Predicted to be active in plasma membrane. Orthologous to human STXBP6 (syntaxin binding protein 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 87.5), Brain (RPKM 74.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stxbp6 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (67647721..67884369, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (61920756..62157405, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (65086483..65319527, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene enolase 1, pseudogene 32 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 92 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U7 small nuclear RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PI(4,5)P(2)-dependent regulation of exocytosis by amisyn, the vertebrate-specific competitor of synaptobrevin 2. Kondratiuk I, et al. Proc Natl Acad Sci U S A, 2020 Jun 16. PMID 32467162, Free PMC Article
    2. Amisyn regulates exocytosis and fusion pore stability by both syntaxin-dependent and syntaxin-independent mechanisms. Constable JR, et al. J Biol Chem, 2005 Sep 9. PMID 16033762
    3. Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly. Scales SJ, et al. J Biol Chem, 2002 Aug 2. PMID 12145319
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PI(4,5)P2-dependent regulation of exocytosis by amisyn, the vertebrate-specific competitor of synaptobrevin 2.
      Title: PI(4,5)P(2)-dependent regulation of exocytosis by amisyn, the vertebrate-specific competitor of synaptobrevin 2.
    2. Amisyn is a novel syntaxin-binding protein that may regulate SNARE complex assembly.
      Title: Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly.
    3. Can negatively regulate exocytosis independently of syntaxin and can also regulate the stability of the fusion pore.
      Title: Amisyn regulates exocytosis and fusion pore stability by both syntaxin-dependent and syntaxin-independent mechanisms.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of SNARE complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of SNARE complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of SNARE complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin-binding protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191872.1 → NP_001178801.1  syntaxin-binding protein 6

      See identical proteins and their annotated locations for NP_001178801.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZQ52, A0A8I6A7D8
      Related
      ENSRNOP00000005618.6, ENSRNOT00000005618.6
      Conserved Domains (2) summary
      cd14681
      Location:2 → 131
      PH-STXBP6; PH-like domain of Syntaxin binding protein 6
      cd15892
      Location:149 → 210
      R-SNARE_STXBP6; SNARE domain of STXBP6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      67647721..67884369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262101.1 → XP_063118171.1  syntaxin-binding protein 6 isoform X2

    2. XM_008764658.4 → XP_008762880.1  syntaxin-binding protein 6 isoform X1

      See identical proteins and their annotated locations for XP_008762880.1

      UniProtKB/TrEMBL
      A0A8I5ZQ52, A0A8I6A7D8
      Conserved Domains (2) summary
      cd14681
      Location:2 → 131
      PH-STXBP6; PH-like domain of Syntaxin binding protein 6
      cd15892
      Location:149 → 210
      R-SNARE_STXBP6; SNARE domain of STXBP6
    Nucleotide Protein Strain
    Heading Accession and Version

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