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    Zdhhc1 zinc finger, DHHC-type containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291967, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Zdhhc1provided by RGD
    Official Full Name
    zinc finger, DHHC-type containing 1provided by RGD
    Primary source
    RGD:1589775
    See related
    Ensembl:ENSRNOG00000017045 AllianceGenome:RGD:1589775
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of defense response to virus by host. Predicted to act upstream of or within protein palmitoylation. Predicted to be located in endoplasmic reticulum membrane and endosome membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC1 (zinc finger DHHC-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 67.9), Lung (RPKM 61.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zdhhc1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50260445..50285634, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33350533..33375717, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37428959..37454150, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 19 Neighboring gene leucine rich repeat containing 36 Neighboring gene tubulin polymerization-promoting protein family member 3 Neighboring gene hydroxysteroid 11-beta dehydrogenase 2 Neighboring gene ATPase H+ transporting V0 subunit D1 Neighboring gene uncharacterized LOC134483348

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Zhou Q, et al. Cell Host Microbe, 2014 Oct 8. PMID 25299331
    2. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. Oku S, et al. J Biol Chem, 2013 Jul 5. PMID 23687301, Free PMC Article
    3. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741
    4. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. Ohno Y, et al. Mol Biol Cell, 2012 Dec. PMID 23034182, Free PMC Article
    5. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
      Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein oligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC1
    Names
    membrane-associated DHHC1 zinc finger protein
    probable palmitoyltransferase ZDHHC1
    zinc finger, DHHC domain containing 1
    NP_001034188.1
    XP_008770707.1
    XP_017456714.1
    XP_017456715.1
    XP_017456716.1
    XP_017456717.1
    XP_017456718.1
    XP_038953542.1
    XP_038953543.1
    XP_063133985.1
    XP_063133987.1
    XP_063133988.1
    XP_063133989.1
    XP_063133990.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039099.1 → NP_001034188.1  palmitoyltransferase ZDHHC1

      See identical proteins and their annotated locations for NP_001034188.1

      Status: PROVISIONAL

      Source sequence(s)
      AY886520
      UniProtKB/TrEMBL
      F7F2Z1, Q2TGK5
      Conserved Domains (1) summary
      pfam01529
      Location:126 → 281
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50260445..50285634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601227.3 → XP_017456716.1  palmitoyltransferase ZDHHC1 isoform X2

      UniProtKB/TrEMBL
      F7F2Z1, Q2TGK5
      Related
      ENSRNOP00000060094.2
      Conserved Domains (1) summary
      pfam01529
      Location:126 → 281
      zf-DHHC; DHHC palmitoyltransferase

    2. XM_017601228.3 → XP_017456717.1  palmitoyltransferase ZDHHC1 isoform X3

    3. XM_017601225.3 → XP_017456714.1  palmitoyltransferase ZDHHC1 isoform X1

      UniProtKB/TrEMBL
      F7F2Z1
      Conserved Domains (1) summary
      pfam01529
      Location:126 → 281
      DHHC; DHHC palmitoyltransferase

    4. XM_017601229.3 → XP_017456718.1  palmitoyltransferase ZDHHC1 isoform X4

    5. XM_063277917.1 → XP_063133987.1  palmitoyltransferase ZDHHC1 isoform X4

    6. XM_063277918.1 → XP_063133988.1  palmitoyltransferase ZDHHC1 isoform X5

    7. XM_063277919.1 → XP_063133989.1  palmitoyltransferase ZDHHC1 isoform X5

    8. XM_008772485.4 → XP_008770707.1  palmitoyltransferase ZDHHC1 isoform X1

      UniProtKB/TrEMBL
      F7F2Z1
      Conserved Domains (1) summary
      pfam01529
      Location:126 → 281
      DHHC; DHHC palmitoyltransferase

    9. XM_063277915.1 → XP_063133985.1  palmitoyltransferase ZDHHC1 isoform X2

      UniProtKB/TrEMBL
      Q2TGK5

    10. XM_017601226.3 → XP_017456715.1  palmitoyltransferase ZDHHC1 isoform X1

      UniProtKB/TrEMBL
      F7F2Z1
      Conserved Domains (1) summary
      pfam01529
      Location:126 → 281
      DHHC; DHHC palmitoyltransferase

    11. XM_039097614.2 → XP_038953542.1  palmitoyltransferase ZDHHC1 isoform X6

    12. XM_039097615.2 → XP_038953543.1  palmitoyltransferase ZDHHC1 isoform X6

    13. XM_063277920.1 → XP_063133990.1  palmitoyltransferase ZDHHC1 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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