Ptprf protein tyrosine phosphatase, receptor type, F [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptprfprovided by RGD
Official Full Name: protein tyrosine phosphatase, receptor type, Fprovided by RGD
Primary source: RGD:3453
See related: Ensembl:ENSRNOG00000019977 AllianceGenome:RGD:3453
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LARFN5C
Summary: Enables phosphate ion binding activity; signaling receptor binding activity; and transmembrane receptor protein tyrosine phosphatase activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; negative regulation of signal transduction; and regulation of cell projection organization. Located in several cellular components, including excitatory synapse; growth cone; and neuronal cell body. Is integral component of postsynaptic density membrane. Biomarker of obesity. Human ortholog(s) of this gene implicated in hyperinsulinism. Orthologous to human PTPRF (protein tyrosine phosphatase receptor type F). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 299.7), Kidney (RPKM 217.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (137027376..137109405, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (131741959..131824000, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (137036936..137112930, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In a spinal cord injury model, blocking LAR and PTPalpha receptors promotes oligodendrogenesis.
Title: LAR and PTPσ receptors are negative regulators of oligodendrogenesis and oligodendrocyte integrity in spinal cord injury.
This study showed that astrocytes aberrantly and progressively expressed PTPsigma and LAR at the site of motor neuron degeneration in Tg ALS model rats with mutant SOD1.
Title: Aberrant astrocytic expression of chondroitin sulfate proteoglycan receptors in a rat model of amyotrophic lateral sclerosis.
a novel, liver specific, truncated isoform of the LAR transcript transcribed under the control of an intronic promoter
Title: A novel liver specific isoform of the rat LAR transcript is expressed as a truncated isoform encoded from a 5'UTR located within intron 11.
Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.
Title: Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.
results suggest that LARFN5C, a small ectodomain isoform, can function as a homophilic ligand to promote neurite outgrowth
Title: Leukocyte antigen-related protein tyrosine phosphatase receptor: a small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth.
Physiological pathway from the cell matrix to increased prolactin gene transcription mediated by phosphatidylinositol 3-kinase and cytoskeletal RPTPalpha/Src/Rho/phosphatidylinositol 3-kinase and cytoskeletal changes.
Title: Integrin activates receptor-like protein tyrosine phosphatase alpha, Src, and Rho to increase prolactin gene expression through a final phosphatidylinositol 3-kinase/cytoskeletal pathway that is additive with insulin.
RPTPalpha and LAR may modulate RGC survival, and RPTPalpha, STEP, and LAR may modulate axon growth.
Title: Stimulated regeneration of the crushed adult rat optic nerve correlates with attenuated expression of the protein tyrosine phosphatases RPTPalpha, STEP, and LAR.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fj50d02.y1 (e-PCR)
- UniSTS:199467

RH125034 (e-PCR)
- UniSTS:161856

RH130809 (e-PCR)
- UniSTS:214093

UniSTS:224908 (e-PCR)
- UniSTS:224908

RH139045 (e-PCR)
- UniSTS:221131

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables chondroitin sulfate proteoglycan binding	IEA Inferred from Electronic Annotation more info
enables chondroitin sulfate proteoglycan binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphate ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane receptor protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neurotrophin TRK receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection regeneration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron projection regeneration	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axon regeneration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structure or activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IEA Inferred from Electronic Annotation more info
involved_in synaptic membrane adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IEA Inferred from Electronic Annotation more info
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase F

Names: LAR; leukocyte antigen-related (LAR) PTP receptor; leukocyte common antigen related

NP_062122.2

EC 3.1.3.48

XP_038966082.1

EC 3.1.3.48

XP_038966085.1

EC 3.1.3.48

XP_038966087.1

EC 3.1.3.48

XP_038966089.1

EC 3.1.3.48

XP_038966091.1

EC 3.1.3.48

XP_038966095.1

EC 3.1.3.48

XP_038966096.1

EC 3.1.3.48

XP_038966100.1

EC 3.1.3.48

XP_038966102.1

EC 3.1.3.48

XP_038966103.1

EC 3.1.3.48

XP_038966104.1

EC 3.1.3.48

XP_063143938.1

EC 3.1.3.48

XP_063143939.1

EC 3.1.3.48

XP_063143940.1

EC 3.1.3.48

XP_063143941.1

EC 3.1.3.48

XP_063143942.1

EC 3.1.3.48

XP_063143943.1

EC 3.1.3.48

XP_063143944.1

EC 3.1.3.48

XP_063143945.1

EC 3.1.3.48

XP_063143946.1

EC 3.1.3.48

XP_063143947.1

EC 3.1.3.48

XP_063143948.1

EC 3.1.3.48

XP_063143949.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019249.2 → NP_062122.2 receptor-type tyrosine-protein phosphatase F precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q4JFJ1, Q63294, Q63295, Q63296, Q64604

UniProtKB/TrEMBL

A6JZG5

Related

ENSRNOP00000027271.4, ENSRNOT00000027271.7

Conserved Domains (7) summary

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14629
Location:1603 → 1893

R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:136 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

cl28904
Location:1326 → 1601

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

137027376..137109405 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110175.2 → XP_038966103.1 receptor-type tyrosine-protein phosphatase F isoform X20

UniProtKB/Swiss-Prot

Q4JFJ1, Q63294, Q63295, Q63296, Q64604

Conserved Domains (7) summary

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14629
Location:1308 → 1598

R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:136 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

cl28904
Location:1031 → 1306

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039110168.2 → XP_038966096.1 receptor-type tyrosine-protein phosphatase F isoform X12

UniProtKB/Swiss-Prot

Q4JFJ1, Q63294, Q63295, Q63296, Q64604

Conserved Domains (7) summary

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14629
Location:1501 → 1791

R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:136 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

cl28904
Location:1224 → 1499

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039110167.2 → XP_038966095.1 receptor-type tyrosine-protein phosphatase F isoform X11

UniProtKB/Swiss-Prot

Q4JFJ1, Q63294, Q63295, Q63296, Q64604

Conserved Domains (7) summary

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14629
Location:1512 → 1802

R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:136 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

cl28904
Location:1235 → 1510

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039110174.2 → XP_038966102.1 receptor-type tyrosine-protein phosphatase F isoform X19

UniProtKB/Swiss-Prot

Q4JFJ1, Q63294, Q63295, Q63296, Q64604

UniProtKB/TrEMBL

A0A8I6G9U8

Related

ENSRNOP00000082730.1

Conserved Domains (7) summary

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14629
Location:1328 → 1618

R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:136 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

cl28904
Location:1051 → 1326

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_063287877.1 → XP_063143947.1 receptor-type tyrosine-protein phosphatase F isoform X17

UniProtKB/Swiss-Prot

Q4JFJ1, Q63294, Q63295, Q63296, Q64604
XM_039110163.2 → XP_038966091.1 receptor-type tyrosine-protein phosphatase F isoform X8

UniProtKB/Swiss-Prot

Q4JFJ1, Q63294, Q63295, Q63296, Q64604

UniProtKB/TrEMBL

A6JZG5

Conserved Domains (7) summary

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14629
Location:1603 → 1893

R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:136 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

cl28904
Location:1326 → 1601

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039110159.2 → XP_038966087.1 receptor-type tyrosine-protein phosphatase F isoform X6

UniProtKB/Swiss-Prot

Q4JFJ1, Q63294, Q63295, Q63296, Q64604

Conserved Domains (7) summary

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14629
Location:1614 → 1904

R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:136 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

cl28904
Location:1337 → 1612

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039110161.2 → XP_038966089.1 receptor-type tyrosine-protein phosphatase F isoform X7

UniProtKB/Swiss-Prot

Q4JFJ1, Q63294, Q63295, Q63296, Q64604

UniProtKB/TrEMBL

A0A0G2JT62

Related

ENSRNOP00000068583.2

Conserved Domains (7) summary

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14629
Location:1612 → 1902

R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:136 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

cl28904
Location:1335 → 1610

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039110157.2 → XP_038966085.1 receptor-type tyrosine-protein phosphatase F isoform X2

UniProtKB/Swiss-Prot

Q4JFJ1, Q63294, Q63295, Q63296, Q64604

Conserved Domains (7) summary

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14629
Location:1623 → 1913

R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:136 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

cl28904
Location:1346 → 1621

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039110172.2 → XP_038966100.1 receptor-type tyrosine-protein phosphatase F isoform X18

UniProtKB/TrEMBL

A0A8I5ZVM7

Conserved Domains (7) summary

cd00063
Location:325 → 414

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14629
Location:1334 → 1624

R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:136 → 232

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:241 → 322

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

cl28904
Location:1057 → 1332

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_063287872.1 → XP_063143942.1 receptor-type tyrosine-protein phosphatase F isoform X10

UniProtKB/TrEMBL

A0A8I5ZVM7
XM_063287876.1 → XP_063143946.1 receptor-type tyrosine-protein phosphatase F isoform X16

UniProtKB/TrEMBL

A0A8I5ZVM7
XM_063287874.1 → XP_063143944.1 receptor-type tyrosine-protein phosphatase F isoform X14

UniProtKB/TrEMBL

A0A8I5ZVM7
XM_063287870.1 → XP_063143940.1 receptor-type tyrosine-protein phosphatase F isoform X5

UniProtKB/TrEMBL

A0A8I5ZVM7, G3V8P4
XM_063287868.1 → XP_063143938.1 receptor-type tyrosine-protein phosphatase F isoform X3

UniProtKB/TrEMBL

A0A8I5ZVM7
XM_063287875.1 → XP_063143945.1 receptor-type tyrosine-protein phosphatase F isoform X15

UniProtKB/TrEMBL

A0A8I5ZVM7
XM_063287873.1 → XP_063143943.1 receptor-type tyrosine-protein phosphatase F isoform X13

UniProtKB/TrEMBL

A0A8I5ZVM7
XM_063287869.1 → XP_063143939.1 receptor-type tyrosine-protein phosphatase F isoform X4

UniProtKB/TrEMBL

A0A8I5ZVM7
XM_039110154.2 → XP_038966082.1 receptor-type tyrosine-protein phosphatase F isoform X1

UniProtKB/TrEMBL

A0A8I5ZVM7

Conserved Domains (7) summary

cd00063
Location:325 → 414

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14629
Location:1629 → 1919

R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:136 → 232

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:241 → 322

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

cl28904
Location:1352 → 1627

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_063287879.1 → XP_063143949.1 receptor-type tyrosine-protein phosphatase F isoform X23

UniProtKB/Swiss-Prot

Q4JFJ1, Q63294, Q63295, Q63296, Q64604
XM_063287871.1 → XP_063143941.1 receptor-type tyrosine-protein phosphatase F isoform X9

UniProtKB/TrEMBL

A0A8I5ZVM7
XM_039110176.2 → XP_038966104.1 receptor-type tyrosine-protein phosphatase F isoform X21

UniProtKB/TrEMBL

A6JZG6

Conserved Domains (3) summary

cd00063
Location:140 → 228

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14629
Location:844 → 1134

R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2

cl28904
Location:567 → 842

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_063287878.1 → XP_063143948.1 receptor-type tyrosine-protein phosphatase F isoform X22

UniProtKB/TrEMBL

A6JZG6