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    Polr3c RNA polymerase III subunit C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310685, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Polr3cprovided by RGD
    Official Full Name
    RNA polymerase III subunit Cprovided by RGD
    Primary source
    RGD:1311545
    See related
    Ensembl:ENSRNOG00000033560 AllianceGenome:RGD:1311545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase III complex. Orthologous to human POLR3C (RNA polymerase III subunit C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 66.3), Spleen (RPKM 61.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Polr3c in Genome Data Viewer
    Location:
    2q34
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186935038..186950962, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (184246201..184262150, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198836282..198852368, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100888 Neighboring gene protein inhibitor of activated STAT, 3 Neighboring gene nudix hydrolase 17 Neighboring gene small nucleolar RNA SNORA5 Neighboring gene ring finger protein 115 Neighboring gene CD160 molecule Neighboring gene PDZ domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation. Lefèvre S, et al. Nat Struct Mol Biol, 2011 Mar. PMID 21358628
    2. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Ablasser A, et al. Nat Immunol, 2009 Oct. PMID 19609254, Free PMC Article
    3. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, et al. Cell Cycle, 2010 Sep 15. PMID 20890107, Free PMC Article
    4. Gene duplication and neofunctionalization: POLR3G and POLR3GL. Renaud M, et al. Genome Res, 2014 Jan. PMID 24107381, Free PMC Article
    5. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. Hu P, et al. Mol Cell Biol, 2002 Nov. PMID 12391170, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of interferon-beta production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC3
    Names
    DNA-directed RNA polymerase III subunit C
    RNA polymerase III subunit C3
    polymerase (RNA) III (DNA directed) polypeptide C
    polymerase (RNA) III subunit C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012081.2 → NP_001012081.1  DNA-directed RNA polymerase III subunit RPC3

      See identical proteins and their annotated locations for NP_001012081.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q5XIL3
      UniProtKB/TrEMBL
      A0A8I5ZYW9, A6K394
      Related
      ENSRNOP00000085283.1, ENSRNOT00000100231.1
      Conserved Domains (2) summary
      pfam05645
      Location:146 → 344
      RNA_pol_Rpc82; RNA polymerase III subunit RPC82
      pfam08221
      Location:7 → 65
      HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain

    2. NM_001415056.1 → NP_001401985.1  DNA-directed RNA polymerase III subunit RPC3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q5XIL3
      UniProtKB/TrEMBL
      A6K394

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      186935038..186950962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281889.1 → XP_063137959.1  DNA-directed RNA polymerase III subunit RPC3 isoform X3

    2. XM_039102384.1 → XP_038958312.1  DNA-directed RNA polymerase III subunit RPC3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYW9, A0A8L2QFS6
      Related
      ENSRNOP00000028815.4, ENSRNOT00000028815.6
      Conserved Domains (2) summary
      pfam05645
      Location:157 → 355
      RNA_pol_Rpc82; RNA polymerase III subunit RPC82
      pfam08221
      Location:18 → 79
      HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain

    3. XM_063281888.1 → XP_063137958.1  DNA-directed RNA polymerase III subunit RPC3 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIL3.1 GenPept UniProtKB/Swiss-Prot:Q5XIL3

    Gene LinkOut

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