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    Hs2st1 heparan sulfate 2-O-sulfotransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292155, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hs2st1provided by RGD
    Official Full Name
    heparan sulfate 2-O-sulfotransferase 1provided by RGD
    Primary source
    RGD:1305366
    See related
    Ensembl:ENSRNOG00000012549 AllianceGenome:RGD:1305366
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heparan sulfate 2-O-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification and heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to act upstream of or within gene expression; heparin metabolic process; and ureteric bud formation. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Orthologous to human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 95.9), Lung (RPKM 94.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hs2st1 in Genome Data Viewer
    Location:
    2q44
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (236168391..236302186, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (233508018..233641769, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (250467428..250600517, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350128 Neighboring gene uncharacterized LOC134485991 Neighboring gene uncharacterized LOC102549483 Neighboring gene uncharacterized LOC120100962 Neighboring gene selenoprotein F Neighboring gene uncharacterized LOC120100963

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Chromosome 2 Fragment Substitutions in Dahl Salt-Sensitive Rats and RNA Sequencing Identified Enpep and Hs2st1 as Vascular Inflammatory Modulators. Berillo O, et al. Hypertension, 2021 Jan. PMID 33161775, Free PMC Article
    2. The molecular phenotype of heparan sulfate in the Hs2st-/- mutant mouse. Merry CL, et al. J Biol Chem, 2001 Sep 21. PMID 11457822
    3. Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. Bullock SL, et al. Genes Dev, 1998 Jun 15. PMID 9637690, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chromosome 2 Fragment Substitutions in Dahl Salt-Sensitive Rats and RNA Sequencing Identified Enpep and Hs2st1 as Vascular Inflammatory Modulators.
      Title: Chromosome 2 Fragment Substitutions in Dahl Salt-Sensitive Rats and RNA Sequencing Identified Enpep and Hs2st1 as Vascular Inflammatory Modulators.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparan sulfate 2-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparan sulfate 2-O-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heparin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ureteric bud formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heparan sulfate 2-O-sulfotransferase 1
    NP_001093988.1
    XP_008759717.1
    XP_038957802.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100518.1 → NP_001093988.1  heparan sulfate 2-O-sulfotransferase 1

      See identical proteins and their annotated locations for NP_001093988.1

      Status: PROVISIONAL

      Source sequence(s)
      AY724508, BC091291, BQ194342, CK839839, DY318006, FM092358, FM104316
      UniProtKB/TrEMBL
      A6HW92, G3V7N0
      Related
      ENSRNOP00000016872.4, ENSRNOT00000016872.8
      Conserved Domains (1) summary
      pfam03567
      Location:71 → 326
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      236168391..236302186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761495.4 → XP_008759717.1  heparan sulfate 2-O-sulfotransferase 1 isoform X1

      Conserved Domains (1) summary
      pfam03567
      Location:71 → 327
      Sulfotransfer_2; Sulfotransferase family

    2. XM_039101874.2 → XP_038957802.1  heparan sulfate 2-O-sulfotransferase 1 isoform X2

      Conserved Domains (1) summary
      cl22970
      Location:71 → 161
      Sulfotransfer_2; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version

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