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    Lmbr1l limb development membrane protein 1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300215, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Lmbr1lprovided by RGD
    Official Full Name
    limb development membrane protein 1-likeprovided by RGD
    Primary source
    RGD:1309631
    See related
    Ensembl:ENSRNOG00000061607 AllianceGenome:RGD:1309631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309631
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in several processes, including T cell activation; hematopoietic stem cell differentiation; and negative regulation of canonical Wnt signaling pathway. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human LMBR1L (limb development membrane protein 1 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 107.0), Testes (RPKM 87.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lmbr1l in Genome Data Viewer
    Location:
    7q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131940081..131958832, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130061136..130078101, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140585512..140600797, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C Neighboring gene RHEB like 1 Neighboring gene ribosomal protein L13, pseudogene 3 Neighboring gene desert hedgehog signaling molecule Neighboring gene tubulin, alpha 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lipocalin-interacting-membrane-receptor (LIMR) mediates cellular internalization of beta-lactoglobulin. Fluckinger M, et al. Biochim Biophys Acta, 2008 Jan. PMID 17991420
    2. Antisense down-regulation of lipocalin-interacting membrane receptor expression inhibits cellular internalization of lipocalin-1 in human NT2 cells. Wojnar P, et al. J Biol Chem, 2003 May 2. PMID 12591932
    3. Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display. Wojnar P, et al. J Biol Chem, 2001 Jun 8. PMID 11287427
    4. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Choi JH, et al. Science, 2019 May 10. PMID 31073040, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109220

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hematopoietic stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein LMBR1L
    Names
    limb region 1 like
    limb region 1-like homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013950.1 → NP_001013972.1  protein LMBR1L isoform 2

      See identical proteins and their annotated locations for NP_001013972.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089929
      UniProtKB/TrEMBL
      F1MAN0, Q5FVK3
      Conserved Domains (1) summary
      pfam04791
      Location:28 → 220
      LMBR1; LMBR1-like membrane protein

    2. NM_001395729.1 → NP_001382658.1  protein LMBR1L isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JVJ7
      Related
      ENSRNOP00000069512.1, ENSRNOT00000082375.2
      Conserved Domains (1) summary
      pfam04791
      Location:21 → 452
      LMBR1; LMBR1-like membrane protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      131940081..131958832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078924.2 → XP_038934852.1  protein LMBR1L isoform X4

      Conserved Domains (1) summary
      pfam04791
      Location:32 → 421
      LMBR1; LMBR1-like membrane protein

    2. XM_039078922.2 → XP_038934850.1  protein LMBR1L isoform X1

      Conserved Domains (1) summary
      pfam04791
      Location:21 → 456
      LMBR1; LMBR1-like membrane protein

    3. XM_017594788.3 → XP_017450277.1  protein LMBR1L isoform X2

      Conserved Domains (1) summary
      pfam04791
      Location:28 → 450
      LMBR1; LMBR1-like membrane protein

    4. XM_039078923.2 → XP_038934851.1  protein LMBR1L isoform X3

      Conserved Domains (1) summary
      pfam04791
      Location:21 → 456
      LMBR1; LMBR1-like membrane protein

    5. XM_063263379.1 → XP_063119449.1  protein LMBR1L isoform X5

    6. XM_039078925.2 → XP_038934853.1  protein LMBR1L isoform X6

      Conserved Domains (1) summary
      pfam04791
      Location:1 → 329
      LMBR1; LMBR1-like membrane protein
    Nucleotide Protein Strain
    Heading Accession and Version

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