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    Farsb phenylalanyl-tRNA synthetase subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301544, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Farsbprovided by RGD
    Official Full Name
    phenylalanyl-tRNA synthetase subunit betaprovided by RGD
    Primary source
    RGD:1303210
    See related
    Ensembl:ENSRNOG00000014119 AllianceGenome:RGD:1303210
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Farslb
    Summary
    Predicted to enable phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and protein heterotetramerization. Predicted to be part of phenylalanine-tRNA ligase complex. Orthologous to human FARSB (phenylalanyl-tRNA synthetase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 144.5), Adrenal (RPKM 142.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Farsb in Genome Data Viewer
    Location:
    9q33
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (87336321..87395546, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (79887852..79947082, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (84324456..84383674, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene sphingosine-1-phosphate phosphatase 2 Neighboring gene uncharacterized LOC134480390 Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene U3 small nucleolar RNA-associated protein 14 homolog B-like Neighboring gene acyl-CoA synthetase long-chain family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of human cytosolic phenylalanyl-tRNA synthetase: evidence for kingdom-specific design of the active sites and tRNA binding patterns. Finarov I, et al. Structure, 2010 Mar 10. PMID 20223217
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94847

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to phenylalanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phenylalanine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phenylalanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of phenylalanine-tRNA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phenylalanine-tRNA ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phenylalanine--tRNA ligase beta subunit
    Names
    phenylalanine-tRNA synthetase-like, beta subunit
    phenylalanyl-tRNA synthetase beta chain
    phenylalanyl-tRNA synthetase, beta subunit
    NP_001004252.1
    XP_006245251.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004252.1 → NP_001004252.1  phenylalanine--tRNA ligase beta subunit

      See identical proteins and their annotated locations for NP_001004252.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079364
      UniProtKB/TrEMBL
      F7FM91, Q68FT7
      Related
      ENSRNOP00000097472.1, ENSRNOT00000094684.1
      Conserved Domains (4) summary
      smart00873
      Location:118 → 279
      B3_4; B3/4 domain
      PLN02265
      Location:1 → 589
      PLN02265; probable phenylalanyl-tRNA synthetase beta chain
      cd00769
      Location:392 → 588
      PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
      pfam03484
      Location:310 → 374
      B5; tRNA synthetase B5 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      87336321..87395546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245189.5 → XP_006245251.1  phenylalanine--tRNA ligase beta subunit isoform X1

      UniProtKB/TrEMBL
      A0A8I6ATG0
      Related
      ENSRNOP00000097872.1
      Conserved Domains (4) summary
      smart00873
      Location:118 → 279
      B3_4; B3/4 domain
      PLN02265
      Location:1 → 541
      PLN02265; probable phenylalanyl-tRNA synthetase beta chain
      pfam03484
      Location:310 → 374
      B5; tRNA synthetase B5 domain
      cl00268
      Location:392 → 522
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
    Nucleotide Protein Strain
    Heading Accession and Version

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