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    Elovl1 ELOVL fatty acid elongase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679532, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Elovl1provided by RGD
    Official Full Name
    ELOVL fatty acid elongase 1provided by RGD
    Primary source
    RGD:1587151
    See related
    Ensembl:ENSRNOG00000028448 AllianceGenome:RGD:1587151
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable fatty acid elongase activity. Predicted to be involved in ceramide biosynthetic process; establishment of skin barrier; and fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 432.1), Lung (RPKM 286.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elovl1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (137246781..137251351)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (131961478..131965961)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (137255868..137260486)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene hydroxypyruvate isomerase Neighboring gene SZT2 subunit of KICSTOR complex Neighboring gene mediator complex subunit 8 Neighboring gene uncharacterized LOC103692460 Neighboring gene cell division cycle 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Note on the cytological localization of alkaline phosphatase. LORCH J. Q J Microsc Sci, 1947 Jun. PMID 20253178
    2. The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy. Ofman R, et al. EMBO Mol Med, 2010 Mar. PMID 20166112, Free PMC Article
    3. Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids. Leonard AE, et al. Biochem J, 2000 Sep 15. PMID 10970790, Free PMC Article
    4. Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. Sassa T, et al. Mol Cell Biol, 2013 Jul. PMID 23689133, Free PMC Article
    5. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. Ohno Y, et al. Proc Natl Acad Sci U S A, 2010 Oct 26. PMID 20937905, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid elongase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of skin barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, monounsaturated fatty acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    very long chain fatty acid elongase 1
    Names
    elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
    elongation of very long chain fatty acids protein 1
    NP_001037740.1
    XP_017449105.1
    XP_017449106.1
    XP_017449107.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044275.1 → NP_001037740.1  very long chain fatty acid elongase 1

      See identical proteins and their annotated locations for NP_001037740.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085795
      UniProtKB/TrEMBL
      A0A0G2K8N7, Q5U2Z8
      Conserved Domains (1) summary
      pfam01151
      Location:23 → 260
      ELO; GNS1/SUR4 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      137246781..137251351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593616.3 → XP_017449105.1  very long chain fatty acid elongase 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8N7, Q5U2Z8
      Related
      ENSRNOP00000033374.2
      Conserved Domains (1) summary
      pfam01151
      Location:23 → 260
      ELO; GNS1/SUR4 family

    2. XM_017593618.3 → XP_017449107.1  very long chain fatty acid elongase 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8N7, Q5U2Z8
      Conserved Domains (1) summary
      pfam01151
      Location:23 → 260
      ELO; GNS1/SUR4 family

    3. XM_017593617.3 → XP_017449106.1  very long chain fatty acid elongase 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8N7, Q5U2Z8
      Conserved Domains (1) summary
      pfam01151
      Location:23 → 260
      ELO; GNS1/SUR4 family
    Nucleotide Protein Strain
    Heading Accession and Version

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