Slc34a3 solute carrier family 34 (sodium phosphate), member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc34a3provided by MGI
Official Full Name: solute carrier family 34 (sodium phosphate), member 3provided by MGI
Primary source: MGI:MGI:2159410
See related: Ensembl:ENSMUSG00000006469 AllianceGenome:MGI:2159410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Npt2c; NptIIc; naPi-2c; Npt2c-v1
Summary: Enables sodium:phosphate symporter activity. Acts upstream of or within phosphate ion transport. Located in apical plasma membrane and brush border. Is expressed in several structures, including extraembryonic component; genitourinary system; and small intestine. Human ortholog(s) of this gene implicated in hereditary hypophosphatemic rickets with hypercalciuria. Orthologous to human SLC34A3 (solute carrier family 34 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward kidney adult (RPKM 74.2) See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 17.09 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25118909..25124282, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25228897..25234270, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of sodium-dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages.
Title: Role of sodium-dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages.
Acute regulation of NaPi-IIc protein by parathyroid hormone is involved in the inactivation of Na(+)-dependent Pi cotransporter activity and that phosphorylation of the transporter is involved in the rapid modification.
Title: Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation.
Nampt/NAD(+) system for Npt2 regulation and cellular shifts to tissues such as the liver play an important role in generating daily oscillation of plasma inorganic phosphate levels.
Title: The sodium phosphate cotransporter family and nicotinamide phosphoribosyltransferase contribute to the daily oscillation of plasma inorganic phosphate concentration.
we have generated a renal-specific and inducible knockout model of NaPi-IIc/Slc34a3. absence of NaPi-IIc does not disturb the homeostasis of Pi in mice. However, ablation of the cotransporter in weaning mice does not alter the homeostasis of Ca2+.
Title: Renal-specific and inducible depletion of NaPi-IIc/Slc34a3, the cotransporter mutated in HHRH, does not affect phosphate or calcium homeostasis in mice.
The expression of Npt2c-v1 mRNA was detected in the heart, spleen, testis, uterus, placenta, femur, cerebellum, hippocampus, diencephalon and brain stem and sperm of mouse.
Title: Identification and functional analysis of a splice variant of mouse sodium-dependent phosphate transporter Npt2c.
reduced intestinal Pi absorption in VDR (-/-) mice does not seem to be the only factor that causes hypophosphatemia; reduced Npt2a, Npt2c, or PiT-2 protein levels during development might also cause hypophosphatemia and rickets in VDR (-/-) mice.
Title: Hypophosphatemia in vitamin D receptor null mice: effect of rescue diet on the developmental changes in renal Na+ -dependent phosphate cotransporters.
Targeting of NaPi-IIc to the apical surface of renal epithelial cells is regulated by a unique amino acid motif in the cytoplasmic C-terminal domain.
Title: An apical expression signal of the renal type IIc Na+-dependent phosphate cotransporter in renal epithelial cells.
Findings suggest that Npt2a, Npt2c, and PiT-2 are necessary for the phosphaturic activity of FGF23.
Title: Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice.
Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.
Title: Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.
FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.
Title: FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

Slc34a3 (e-PCR), detects polymorphism
- UniSTS:547082

AI649385 (e-PCR)
- UniSTS:178586

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables sodium:phosphate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:phosphate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:phosphate symporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sodium:phosphate symporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular phosphate ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphate ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphate ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in sodium-dependent phosphate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium-dependent phosphate transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in brush border	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sodium-dependent phosphate transport protein 2C

Names: Na(+)-dependent phosphate cotransporter 2C; Na(+)/Pi cotransporter 2C; sodium-phosphate cotransporter IIC; sodium/phosphate cotransporter 2C; type IIc Na+/Pi-cotransporter; type IIc NaPi-cotransporter-v1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362748.1 → NP_001349677.1 sodium-dependent phosphate transport protein 2C isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL732309

UniProtKB/TrEMBL

A0A0D5ZYC4

Conserved Domains (1) summary

TIGR01013
Location:19 → 505

2a58; Phosphate:Na+ Symporter (PNaS) Family
NM_080854.3 → NP_543130.2 sodium-dependent phosphate transport protein 2C isoform 1

See identical proteins and their annotated locations for NP_543130.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AL732309, BC125326

Consensus CDS

CCDS15754.1

UniProtKB/Swiss-Prot

Q05AC3, Q80SU6

UniProtKB/TrEMBL

A0A0D5ZYC4

Related

ENSMUSP00000006638.8, ENSMUST00000006638.8

Conserved Domains (1) summary

TIGR01013
Location:79 → 565

2a58; Phosphate:Na+ Symporter (PNaS) Family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

25118909..25124282 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497681.3 → XP_006497744.1 sodium-dependent phosphate transport protein 2C isoform X5

See identical proteins and their annotated locations for XP_006497744.1

UniProtKB/TrEMBL

A0A0D5ZYC4

Conserved Domains (1) summary

TIGR01013
Location:19 → 505

2a58; Phosphate:Na+ Symporter (PNaS) Family
XM_006497683.3 → XP_006497746.1 sodium-dependent phosphate transport protein 2C isoform X5

See identical proteins and their annotated locations for XP_006497746.1

UniProtKB/TrEMBL

A0A0D5ZYC4

Conserved Domains (1) summary

TIGR01013
Location:19 → 505

2a58; Phosphate:Na+ Symporter (PNaS) Family
XM_006497679.2 → XP_006497742.1 sodium-dependent phosphate transport protein 2C isoform X3

UniProtKB/TrEMBL

A0A0D5ZYC4

Conserved Domains (1) summary

TIGR01013
Location:72 → 558

2a58; Phosphate:Na+ Symporter (PNaS) Family
XM_006497677.2 → XP_006497740.1 sodium-dependent phosphate transport protein 2C isoform X2

See identical proteins and their annotated locations for XP_006497740.1

UniProtKB/Swiss-Prot

Q05AC3, Q80SU6

UniProtKB/TrEMBL

A0A0D5ZYC4

Conserved Domains (1) summary

TIGR01013
Location:79 → 565

2a58; Phosphate:Na+ Symporter (PNaS) Family
XM_011239018.2 → XP_011237320.1 sodium-dependent phosphate transport protein 2C isoform X4

UniProtKB/TrEMBL

A0A0D5ZYC4

Conserved Domains (1) summary

TIGR01013
Location:87 → 543

2a58; Phosphate:Na+ Symporter (PNaS) Family
XM_011239017.2 → XP_011237319.1 sodium-dependent phosphate transport protein 2C isoform X1

UniProtKB/TrEMBL

A0A0D5ZYC4

Conserved Domains (1) summary

TIGR01013
Location:87 → 573

2a58; Phosphate:Na+ Symporter (PNaS) Family
XM_006497678.2 → XP_006497741.1 sodium-dependent phosphate transport protein 2C isoform X2

See identical proteins and their annotated locations for XP_006497741.1

UniProtKB/Swiss-Prot

Q05AC3, Q80SU6

UniProtKB/TrEMBL

A0A0D5ZYC4

Conserved Domains (1) summary

TIGR01013
Location:79 → 565

2a58; Phosphate:Na+ Symporter (PNaS) Family
XM_017315536.2 → XP_017171025.1 sodium-dependent phosphate transport protein 2C isoform X1

UniProtKB/TrEMBL

A0A0D5ZYC4

Conserved Domains (1) summary

TIGR01013
Location:87 → 573

2a58; Phosphate:Na+ Symporter (PNaS) Family
XM_017315541.2 → XP_017171030.1 sodium-dependent phosphate transport protein 2C isoform X5

UniProtKB/TrEMBL

A0A0D5ZYC4

Conserved Domains (1) summary

TIGR01013
Location:19 → 505

2a58; Phosphate:Na+ Symporter (PNaS) Family