Plch2 phospholipase C, eta 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plch2provided by MGI
Official Full Name: phospholipase C, eta 2provided by MGI
Primary source: MGI:MGI:2443078
See related: Ensembl:ENSMUSG00000029055 AllianceGenome:MGI:2443078
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Plcl4; PLCeta2; Plc-eta2; A930027K05Rik
Summary: Enables phospholipase C activity. Acts upstream of or within phosphatidylinositol metabolic process. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; integumental system; lower urinary tract; and sensory organ. Orthologous to human PLCH2 (phospholipase C eta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 24.6), colon adult (RPKM 15.7) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 86.13 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (155067572..155148548, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (154983115..155064091, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of PLCeta2 in neuritogenesis was assessed during retinoic acid (RA)-induced Neuro2A cell differentiation
Title: Phospholipase C-η2 is required for retinoic acid-stimulated neurite growth.
PLCeta2 exhibited a dynamic expression pattern during postnatal retinal development, strongly suggesting that this isozyme might be involved in the development and maturation of the retina.
Title: Phospholipase C-eta2 is highly expressed in the habenula and retina.
PLC(eta)2 is a neuron-specific isozyme that may be important for the formation and/or maintenance of the neuronal network in the postnatal brain
Title: A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme.
The molecular cloning and sequencing of phospholipase C eta2 are reported.
Title: Molecular cloning and characterization of PLC-eta2.
molecular cloning of PLC-eta1 and PLC-eta2.
Title: Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Mit256 (e-PCR), detects polymorphism
- UniSTS:116758

D4Mit256.2 (e-PCR), detects polymorphism
- UniSTS:130044

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	ISO Inferred from Sequence Orthology more info
enables phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

Names: phosphoinositide phospholipase C-eta-2; phosphoinositide phospholipase C-like 4; phospholipase C-like protein 4

NP_001106831.1

EC 3.1.4.11

NP_001343399.1

EC 3.1.4.11

NP_780765.2

EC 3.1.4.11

XP_006538999.1

EC 3.1.4.11

XP_006539003.1

EC 3.1.4.11

XP_011248570.1

EC 3.1.4.11

XP_011248571.1

EC 3.1.4.11

XP_011248572.1

EC 3.1.4.11

XP_011248573.1

EC 3.1.4.11

XP_011248574.1

EC 3.1.4.11

XP_011248575.1

EC 3.1.4.11

XP_011248576.1

EC 3.1.4.11

XP_011248577.1

EC 3.1.4.11

XP_011248578.1

EC 3.1.4.11

XP_017175736.1

EC 3.1.4.11

XP_036020059.1

EC 3.1.4.11

XP_036020060.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113360.3 → NP_001106831.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform b

See identical proteins and their annotated locations for NP_001106831.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes the longest isoform (b).

Source sequence(s)

AL831788, BX004788

Consensus CDS

CCDS71533.1

UniProtKB/Swiss-Prot

A2AP18, A6PWW5, Q3LUA7, Q4QSC7, Q80WP6, Q8BJV1, Q8BWU4, Q8BXN5, Q8CFR1

UniProtKB/TrEMBL

H3BK11

Related

ENSMUSP00000101256.3, ENSMUST00000105631.9

Conserved Domains (8) summary

cd00275
Location:838 → 963

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08633
Location:399 → 808

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02952
Location:316 → 948

PLN02952; phosphoinositide phospholipase C

cd00051
Location:247 → 313

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd13364
Location:123 → 229

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

pfam00169
Location:141 → 229

PH; PH domain

pfam09279
Location:317 → 399

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam13499
Location:248 → 309

EF-hand_7; EF-hand domain pair
NM_001356470.1 → NP_001343399.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform c

Status: VALIDATED

Source sequence(s)

AK044619, AL831788, BC052329, BC060083, BX004788, CJ113070, DQ176851

UniProtKB/TrEMBL

H3BIW6

Related

ENSMUSP00000134750.2, ENSMUST00000176194.8

Conserved Domains (6) summary

cd08633
Location:318 → 727

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

cd13364
Location:22 → 128

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd15898
Location:146 → 175

EFh_PI-PLC; EF-hand motif [structural motif]

cl26464
Location:916 → 1092

Atrophin-1; Atrophin-1 family

cl27705
Location:288 → 867

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

cl28895
Location:146 → 306

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
NM_175556.5 → NP_780765.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform a

See identical proteins and their annotated locations for NP_780765.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses an alternate splice site and contains an alternate exon in the 3' coding region, resulting in an early stop codon, compared to variant 1. It encodes isoform a, which is shorter and has a distinct C-terminus, compared to isoform b.

Source sequence(s)

AL831788, BX004788

Consensus CDS

CCDS38990.2

UniProtKB/TrEMBL

F7C3A0, F8VQ50, H3BIW6

Related

ENSMUSP00000122704.3, ENSMUST00000139976.9

Conserved Domains (8) summary

cd00275
Location:838 → 963

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08633
Location:399 → 808

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02952
Location:316 → 948

PLN02952; phosphoinositide phospholipase C

cd00051
Location:247 → 313

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd13364
Location:123 → 229

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

pfam00169
Location:141 → 229

PH; PH domain

pfam09279
Location:317 → 399

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam13499
Location:248 → 309

EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

155067572..155148548 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250270.1 → XP_011248572.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X4

See identical proteins and their annotated locations for XP_011248572.1

Conserved Domains (6) summary

cd08633
Location:336 → 745

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02228
Location:306 → 885

PLN02228; Phosphoinositide phospholipase C

PHA03247
Location:934 → 1426

PHA03247; large tegument protein UL36; Provisional

cd13364
Location:40 → 146

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd15898
Location:164 → 193

EFh_PI-PLC; EF-hand motif [structural motif]

cl28895
Location:164 → 324

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
XM_011250271.4 → XP_011248573.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X4

See identical proteins and their annotated locations for XP_011248573.1

Conserved Domains (6) summary

cd08633
Location:336 → 745

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02228
Location:306 → 885

PLN02228; Phosphoinositide phospholipase C

PHA03247
Location:934 → 1426

PHA03247; large tegument protein UL36; Provisional

cd13364
Location:40 → 146

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd15898
Location:164 → 193

EFh_PI-PLC; EF-hand motif [structural motif]

cl28895
Location:164 → 324

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
XM_006538940.2 → XP_006539003.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X7

Related

ENSMUSP00000118292.3, ENSMUST00000135665.9

Conserved Domains (5) summary

cd08633
Location:469 → 878

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02228
Location:391 → 1018

PLN02228; Phosphoinositide phospholipase C

PHA03247
Location:1065 → 1391

PHA03247; large tegument protein UL36; Provisional

cd13364
Location:193 → 299

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd16221
Location:317 → 457

EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
XM_036164167.1 → XP_036020060.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X12

UniProtKB/TrEMBL

H3BIW6

Conserved Domains (4) summary

cd08633
Location:469 → 878

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02228
Location:391 → 1018

PLN02228; Phosphoinositide phospholipase C

cd13364
Location:193 → 299

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd16221
Location:317 → 457

EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
XM_006538936.2 → XP_006538999.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X2

Conserved Domains (5) summary

cd08633
Location:469 → 878

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02228
Location:391 → 1018

PLN02228; Phosphoinositide phospholipase C

PHA03247
Location:1067 → 1559

PHA03247; large tegument protein UL36; Provisional

cd13364
Location:193 → 299

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd16221
Location:317 → 457

EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
XM_017320247.1 → XP_017175736.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X9

UniProtKB/TrEMBL

H3BIW6

Conserved Domains (5) summary

cd08633
Location:469 → 878

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02228
Location:391 → 1018

PLN02228; Phosphoinositide phospholipase C

PHA03247
Location:1067 → 1243

PHA03247; large tegument protein UL36; Provisional

cd13364
Location:193 → 299

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd16221
Location:317 → 457

EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
XM_011250272.1 → XP_011248574.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X5

Conserved Domains (6) summary

cd08633
Location:489 → 898

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02228
Location:459 → 1038

PLN02228; Phosphoinositide phospholipase C

PHA03247
Location:1085 → 1411

PHA03247; large tegument protein UL36; Provisional

cd13364
Location:193 → 299

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd15898
Location:317 → 346

EFh_PI-PLC; EF-hand motif [structural motif]

cl28895
Location:317 → 477

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
XM_011250276.2 → XP_011248578.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X11

UniProtKB/TrEMBL

H3BIW6

Conserved Domains (5) summary

cd08633
Location:489 → 898

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02228
Location:459 → 1038

PLN02228; Phosphoinositide phospholipase C

cd13364
Location:193 → 299

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd15898
Location:317 → 346

EFh_PI-PLC; EF-hand motif [structural motif]

cl28895
Location:317 → 477

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
XM_036164166.1 → XP_036020059.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X11

UniProtKB/TrEMBL

H3BIW6

Conserved Domains (5) summary

cd08633
Location:489 → 898

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02228
Location:459 → 1038

PLN02228; Phosphoinositide phospholipase C

cd13364
Location:193 → 299

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd15898
Location:317 → 346

EFh_PI-PLC; EF-hand motif [structural motif]

cl28895
Location:317 → 477

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
XM_011250268.1 → XP_011248570.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X1

Conserved Domains (6) summary

cd08633
Location:489 → 898

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02228
Location:459 → 1038

PLN02228; Phosphoinositide phospholipase C

PHA03247
Location:1087 → 1579

PHA03247; large tegument protein UL36; Provisional

cd13364
Location:193 → 299

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd15898
Location:317 → 346

EFh_PI-PLC; EF-hand motif [structural motif]

cl28895
Location:317 → 477

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
XM_011250274.2 → XP_011248576.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X8

UniProtKB/TrEMBL

H3BIW6

Conserved Domains (6) summary

cd08633
Location:489 → 898

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02228
Location:459 → 1038

PLN02228; Phosphoinositide phospholipase C

PHA03247
Location:1087 → 1263

PHA03247; large tegument protein UL36; Provisional

cd13364
Location:193 → 299

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd15898
Location:317 → 346

EFh_PI-PLC; EF-hand motif [structural motif]

cl28895
Location:317 → 477

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
XM_011250269.2 → XP_011248571.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X3

Conserved Domains (6) summary

cd08633
Location:341 → 750

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02228
Location:311 → 890

PLN02228; Phosphoinositide phospholipase C

PHA03247
Location:939 → 1431

PHA03247; large tegument protein UL36; Provisional

cd13364
Location:45 → 151

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd15898
Location:169 → 198

EFh_PI-PLC; EF-hand motif [structural motif]

cl28895
Location:169 → 329

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
XM_011250273.3 → XP_011248575.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X6

Conserved Domains (6) summary

cd08633
Location:318 → 727

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02228
Location:288 → 867

PLN02228; Phosphoinositide phospholipase C

PHA03247
Location:916 → 1408

PHA03247; large tegument protein UL36; Provisional

cd13364
Location:22 → 128

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd15898
Location:146 → 175

EFh_PI-PLC; EF-hand motif [structural motif]

cl28895
Location:146 → 306

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
XM_011250275.2 → XP_011248577.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X10

Conserved Domains (5) summary

cd08633
Location:489 → 898

PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2

PLN02228
Location:459 → 1038

PLN02228; Phosphoinositide phospholipase C

cd13364
Location:193 → 299

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd15898
Location:317 → 346

EFh_PI-PLC; EF-hand motif [structural motif]

cl28895
Location:317 → 477

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes