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    Rasgef1c RasGEF domain family, member 1C [ Mus musculus (house mouse) ]

    Gene ID: 74563, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rasgef1cprovided by MGI
    Official Full Name
    RasGEF domain family, member 1Cprovided by MGI
    Primary source
    MGI:MGI:1921813
    See related
    Ensembl:ENSMUSG00000020374 AllianceGenome:MGI:1921813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130006A14Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase mediated signal transduction. Is expressed in olfactory cortex marginal layer; rest of cerebellum marginal layer; and ventral grey horn. Orthologous to human RASGEF1C (RasGEF domain family member 1C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 9.1), cortex adult (RPKM 7.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rasgef1c in Genome Data Viewer
    Location:
    11 B1.2- B1.3; 11 30.02 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49791996..49871050)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49901169..49980223)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29382 Neighboring gene predicted gene, 36507 Neighboring gene STARR-seq mESC enhancer starr_29384 Neighboring gene glutamine fructose-6-phosphate transaminase 2 Neighboring gene STARR-positive B cell enhancer ABC_E5221 Neighboring gene mitogen-activated protein kinase 9 Neighboring gene predicted gene, 53699 Neighboring gene ring finger protein 130 Neighboring gene microRNA 340 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-GEF domain-containing family member 1C

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347462.1 → NP_001334391.1  ras-GEF domain-containing family member 1C isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK018593, AK039330, BX639019
      Consensus CDS
      CCDS83798.1
      UniProtKB/TrEMBL
      B1ATE5
      Related
      ENSMUSP00000065619.3, ENSMUST00000063444.3

    2. NM_029004.1 → NP_083280.1  ras-GEF domain-containing family member 1C isoform 2

      See identical proteins and their annotated locations for NP_083280.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK018593, AK047088, BX639019
      Consensus CDS
      CCDS24625.1
      UniProtKB/Swiss-Prot
      Q8BYJ7, Q9D300
      UniProtKB/TrEMBL
      B1ATE5
      Related
      ENSMUSP00000090829.6, ENSMUST00000093142.12
      Conserved Domains (2) summary
      cd06224
      Location:42 → 157
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:204 → 395
      RasGEF; RasGEF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      49791996..49871050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246404.1 → XP_030102264.1  ras-GEF domain-containing family member 1C isoform X2

      UniProtKB/Swiss-Prot
      Q8BYJ7, Q9D300
      UniProtKB/TrEMBL
      B1ATE5
      Conserved Domains (2) summary
      cd06224
      Location:42 → 157
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:204 → 395
      RasGEF; RasGEF domain

    2. XM_006534378.4 → XP_006534441.2  ras-GEF domain-containing family member 1C isoform X1

      UniProtKB/TrEMBL
      B1ATE5
      Conserved Domains (2) summary
      cd06224
      Location:42 → 157
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:204 → 395
      RasGEF; RasGEF domain

    3. XM_030246405.1 → XP_030102265.1  ras-GEF domain-containing family member 1C isoform X2

      UniProtKB/Swiss-Prot
      Q8BYJ7, Q9D300
      UniProtKB/TrEMBL
      B1ATE5
      Conserved Domains (2) summary
      cd06224
      Location:42 → 157
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:204 → 395
      RasGEF; RasGEF domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D300.1 GenPept UniProtKB/Swiss-Prot:Q9D300

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