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    Gbp9 guanylate-binding protein 9 [ Mus musculus (house mouse) ]

    Gene ID: 236573, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Gbp9provided by MGI
    Official Full Name
    guanylate-binding protein 9provided by MGI
    Primary source
    MGI:MGI:3605620
    See related
    Ensembl:ENSMUSG00000029298 AllianceGenome:MGI:3605620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within adhesion of symbiont to host and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is expressed in meninges and thymus primordium. Orthologous to human GBP6 (guanylate binding protein family member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 6.1), lung adult (RPKM 5.7) and 25 other tissues See more
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    Genomic context

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    See Gbp9 in Genome Data Viewer
    Location:
    5 E5; 5 50.68 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105224331..105258255, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105076464..105110357, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13846 Neighboring gene Sec61 beta subunit pseudogene Neighboring gene guanylate-binding protein 8 Neighboring gene STARR-seq mESC enhancer starr_13847 Neighboring gene guanylate binding protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E1304 Neighboring gene predicted gene, 53274

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies. Kresse A, et al. BMC Genomics, 2008 Apr 10. PMID 18402675, Free PMC Article
    2. Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. Degrandi D, et al. J Immunol, 2007 Dec 1. PMID 18025219
    3. Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Simpson DS, et al. Immunity, 2022 Mar 8. PMID 35139355, Free PMC Article
    4. A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection. Kim BH, et al. Science, 2011 May 6. PMID 21551061
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • E430029F06

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adhesion of symbiont to host IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to type II interferon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to protozoan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to protozoan IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in symbiont-containing vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanylate binding protein family, member 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424671.1 → NP_001411600.1  guanylate binding protein family, member 9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC144914
      UniProtKB/TrEMBL
      Q8BTS3

    2. NM_001424672.1 → NP_001411601.1  guanylate binding protein family, member 9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC144914

    3. NM_172777.5 → NP_766365.1  guanylate binding protein family, member 9 isoform 1

      See identical proteins and their annotated locations for NP_766365.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
      Source sequence(s)
      AC144914
      Consensus CDS
      CCDS39191.1
      UniProtKB/TrEMBL
      Q6PG83, Q8BTS3
      Related
      ENSMUSP00000031238.7, ENSMUST00000031238.13
      Conserved Domains (2) summary
      pfam02263
      Location:16 → 279
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:281 → 575
      GBP_C; Guanylate-binding protein, C-terminal domain

    RNA

    1. NR_153378.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 3' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC144914

    2. NR_188839.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC144914

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      105224331..105258255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004942512.1 RNA Sequence

      Related
      ENSMUST00000196820.5

    2. XR_003955638.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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