Lypd3 Ly6/Plaur domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lypd3provided by MGI
Official Full Name: Ly6/Plaur domain containing 3provided by MGI
Primary source: MGI:MGI:1919684
See related: Ensembl:ENSMUSG00000057454 AllianceGenome:MGI:1919684
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C4.4a; 2310061G07Rik
Summary: Predicted to enable laminin binding activity. Predicted to act upstream of or within cell-matrix adhesion. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including epithelium; foregut; sensory organ; skin; and thymus. Orthologous to human LYPD3 (LY6/PLAUR domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 103.6), bladder adult (RPKM 19.2) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 11.95 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24335995..24340543)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (24636570..24641118)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results are consistent with previous data in mouse embryogenesis and wound healing. Based on these findings, we conclude that this human TES model provides an excellent surrogate for studies of C4.4A and Haldisin expressions in human stratified epithelia.
Title: Expression of C4.4A in an In Vitro Human Tissue-Engineered Skin Model.
the first C4.4A-deficient mouse line was characterized to gain insight into the functional significance of C4.4A in normal physiology and cancer progression.
Title: C4.4A gene ablation is compatible with normal epidermal development and causes modest overt phenotypes.
a possible functional role of C4.4A in early differentiation of stratified squamous epithelia
Title: Expression of C4.4A, a structural uPAR homolog, reflects squamous epithelial differentiation in the adult mouse and during embryogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables laminin binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell motility	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cell-matrix adhesion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ly6/PLAUR domain-containing protein 3

Names: GPI-anchored metastasis-associated protein C4.4A homolog; GPI-anchored metastasis-associated protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133743.1 → NP_598504.1 ly6/PLAUR domain-containing protein 3 precursor

See identical proteins and their annotated locations for NP_598504.1

Status: PROVISIONAL

Source sequence(s)

BC016549

Consensus CDS

CCDS20958.1

UniProtKB/Swiss-Prot

Q91YK8

Related

ENSMUSP00000079543.5, ENSMUST00000080718.6

Conserved Domains (2) summary

cd00117
Location:33 → 118

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

pfam00021
Location:142 → 224

UPAR_LY6; u-PAR/Ly-6 domain