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    Plekhh3 pleckstrin homology, MyTH4 and FERM domain containing H3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360634, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Plekhh3provided by RGD
    Official Full Name
    pleckstrin homology, MyTH4 and FERM domain containing H3provided by RGD
    Primary source
    RGD:1304854
    See related
    Ensembl:ENSRNOG00000020238 AllianceGenome:RGD:1304854
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304854
    Summary
    Predicted to be involved in signal transduction. Predicted to be located in cytoskeleton. Orthologous to human PLEKHH3 (pleckstrin homology, MyTH4 and FERM domain containing H3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 91.1), Heart (RPKM 63.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekhh3 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86598749..86607482, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86098461..86106931, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89076467..89084952, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene tubulin, gamma 1 Neighboring gene tubulin, gamma 2 Neighboring gene contactin associated protein 1 Neighboring gene C-C motif chemokine receptor 10 Neighboring gene enhancer of zeste 1 polycomb repressive complex 2 subunit Neighboring gene uncharacterized LOC134480876

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC124855

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family H member 3
    Names
    PH domain-containing family H member 3
    pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037202.1 → NP_001032279.1  pleckstrin homology domain-containing family H member 3 precursor

      See identical proteins and their annotated locations for NP_001032279.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107561
      UniProtKB/Swiss-Prot
      Q3B7L1
      UniProtKB/TrEMBL
      A0A8I6A8P7
      Related
      ENSRNOP00000087912.1, ENSRNOT00000110148.1
      Conserved Domains (6) summary
      cd13297
      Location:84 → 208
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      pfam00169
      Location:96 → 199
      PH; PH domain
      pfam00784
      Location:288 → 397
      MyTH4; MyTH4 domain
      cl00155
      Location:409 → 496
      UBQ; Ubiquitin-like proteins
      cl09511
      Location:511 → 550
      FERM_B-lobe; FERM domain B-lobe
      cl17171
      Location:658 → 745
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86598749..86607482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247365.5 → XP_006247427.1  pleckstrin homology domain-containing family H member 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8P7, A0A8L2QGA8
      Related
      ENSRNOP00000027452.6
      Conserved Domains (5) summary
      cd13297
      Location:84 → 208
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      pfam00784
      Location:288 → 397
      MyTH4; MyTH4 domain
      cl09511
      Location:514 → 553
      FERM_B-lobe; FERM domain B-lobe
      cl17171
      Location:661 → 748
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:401 → 500
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B7L1.1 GenPept UniProtKB/Swiss-Prot:Q3B7L1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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