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    Tnpo3 transportin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296954, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Tnpo3provided by RGD
    Official Full Name
    transportin 3provided by RGD
    Primary source
    RGD:1308938
    See related
    Ensembl:ENSRNOG00000021758 AllianceGenome:RGD:1308938
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and small GTPase binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in annulate lamellae and nuclear envelope. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 2. Orthologous to human TNPO3 (transportin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 174.3), Thymus (RPKM 171.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnpo3 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (59108278..59197012, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (58142954..58220365, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56820023..56897310, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene kielin cysteine rich BMP regulator Neighboring gene interferon regulatory factor 5 Neighboring gene uncharacterized LOC134486568 Neighboring gene uncharacterized LOC102552812 Neighboring gene uncharacterized LOC134486745

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel mutation in TNPO3 causes congenital limb-girdle myopathy with slow progression. Vihola A, et al. Neurol Genet, 2019 Jun. PMID 31192305, Free PMC Article
    2. The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection. Rodríguez-Mora S, et al. PLoS Pathog, 2019 Aug. PMID 31465518, Free PMC Article
    3. Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6. Jang S, et al. Nucleic Acids Res, 2019 May 21. PMID 30916345, Free PMC Article
    4. Structural basis for nuclear import of splicing factors by human Transportin 3. Maertens GN, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24449914, Free PMC Article
    5. Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPase. Taltynov O, et al. J Biol Chem, 2013 Aug 30. PMID 23878195, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in annulate lamellae ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transportin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106587.1 → NP_001100057.1  transportin-3

      See identical proteins and their annotated locations for NP_001100057.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473959
      UniProtKB/TrEMBL
      A0A8I6G251, A6IEE3
      Related
      ENSRNOP00000078660.1, ENSRNOT00000113944.1
      Conserved Domains (2) summary
      smart00913
      Location:33 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:121 → 248
      Xpo1; Exportin 1-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      59108278..59197012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285739.1 → XP_063141809.1  transportin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G251

    2. XM_006236186.5 → XP_006236248.1  transportin-3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G251
      Conserved Domains (1) summary
      pfam08389
      Location:55 → 182
      Xpo1; Exportin 1-like protein

    3. XM_039107279.2 → XP_038963207.1  transportin-3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G251
      Conserved Domains (2) summary
      smart00913
      Location:33 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:121 → 248
      Xpo1; Exportin 1-like protein
    Nucleotide Protein Strain
    Heading Accession and Version

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