Mto1 mitochondrial tRNA translation optimization 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mto1provided by RGD
Official Full Name: mitochondrial tRNA translation optimization 1provided by RGD
Primary source: RGD:1308830
See related: Ensembl:ENSRNOG00000037659 AllianceGenome:RGD:1308830
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable flavin adenine dinucleotide binding activity. Predicted to be involved in mitochondrial tRNA wobble uridine modification and tRNA methylation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 10. Orthologous to human MTO1 (mitochondrial tRNA translation optimization 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 83.6), Kidney (RPKM 83.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (88188918..88215516)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (79309681..79335231)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (85807703..85832263)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircMTO1 Attenuated Acute Kidney Injury Through Regulating miR-337.
Title: CircMTO1 Attenuated Acute Kidney Injury Through Regulating miR-337.

Submit: New GeneRIF Correction

General gene information

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Markers

AW532304 (e-PCR)
- UniSTS:245570

RH143356 (e-PCR)
- UniSTS:232603

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitochondrial tRNA wobble uridine modification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial tRNA wobble uridine modification	ISO Inferred from Sequence Orthology more info
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tRNA wobble uridine modification	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein MTO1 homolog, mitochondrial

Names: mitochondrial translation optimization 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106841.1 → NP_001100311.1 protein MTO1 homolog, mitochondrial

See identical proteins and their annotated locations for NP_001100311.1

Status: PROVISIONAL

Source sequence(s)

CH473954

UniProtKB/TrEMBL

A6I1J8, F1LYH3

Related

ENSRNOP00000053966.5, ENSRNOT00000057138.5

Conserved Domains (3) summary

PRK05192
Location:56 → 669

PRK05192; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated

pfam13932
Location:437 → 653

GIDA_assoc; GidA associated domain

cl21454
Location:357 → 455

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

88188918..88215516

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081156.2 → XP_038937084.1 protein MTO1 homolog, mitochondrial isoform X1

Conserved Domains (1) summary

PRK05192
Location:72 → 563

PRK05192; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG
XM_039081158.2 → XP_038937086.1 protein MTO1 homolog, mitochondrial isoform X3

Conserved Domains (1) summary

PRK05192
Location:56 → 419

PRK05192; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG
XM_039081157.2 → XP_038937085.1 protein MTO1 homolog, mitochondrial isoform X2

Conserved Domains (1) summary

PRK05192
Location:2 → 487

PRK05192; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG