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    Myo19 myosin XIX [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497974, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Myo19provided by RGD
    Official Full Name
    myosin XIXprovided by RGD
    Primary source
    RGD:1559961
    See related
    Ensembl:ENSRNOG00000002852 AllianceGenome:RGD:1559961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559961
    Summary
    Predicted to enable ATP hydrolysis activity; cytoskeletal protein binding activity; and plus-end directed microfilament motor activity. Predicted to be involved in several processes, including actin filament organization; regulation of mitochondrial fission; and vesicle transport along actin filament. Predicted to act upstream of or within mitochondrion migration along actin filament. Predicted to be located in cytosol and mitochondrial outer membrane. Predicted to be part of myosin complex. Predicted to be active in actin cytoskeleton; cytoplasm; and vesicle. Orthologous to human MYO19 (myosin XIX). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 101.8), Heart (RPKM 86.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myo19 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70250500..70279867)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (69753082..69782450)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72198475..72227892)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene gametogenetin binding protein 2 Neighboring gene zinc finger, HIT-type containing 3 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class W Neighboring gene U6 spliceosomal RNA Neighboring gene cytochrome c oxidase subunit 7B, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Positively charged residues within the MYO19 MyMOMA domain are essential for proper localization of MYO19 to the mitochondrial outer membrane. Hawthorne JL, et al. Cytoskeleton (Hoboken), 2016 Jun. PMID 27126804, Free PMC Article
    2. Myo19 ensures symmetric partitioning of mitochondria and coupling of mitochondrial segregation to cell division. Rohn JL, et al. Curr Biol, 2014 Nov 3. PMID 25447992, Free PMC Article
    3. Biochemical and bioinformatic analysis of the myosin-XIX motor domain. Adikes RC, et al. Cytoskeleton (Hoboken), 2013 May. PMID 23568824, Free PMC Article
    4. Human Myo19 is a novel myosin that associates with mitochondria. Quintero OA, et al. Curr Biol, 2009 Dec 15. PMID 19932026, Free PMC Article
    5. Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular motor. Lu Z, et al. J Biol Chem, 2014 Jun 27. PMID 24825904, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin light chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables plus-end directed microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitochondrion migration along actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle transport along actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-XIX

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163736.1 → NP_001157208.1  unconventional myosin-XIX

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HHM6, D3Z8I9
      Related
      ENSRNOP00000003886.3, ENSRNOT00000003886.7
      Conserved Domains (3) summary
      smart00242
      Location:38 → 754
      MYSc; Myosin. Large ATPases
      cd14880
      Location:49 → 746
      MYSc_Myo19; class XIX myosin, motor domain
      pfam00612
      Location:784 → 804
      IQ; IQ calmodulin-binding motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      70250500..70279867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269649.1 → XP_063125719.1  unconventional myosin-XIX isoform X1

    2. XM_063269651.1 → XP_063125721.1  unconventional myosin-XIX isoform X2

    3. XM_039086621.2 → XP_038942549.1  unconventional myosin-XIX isoform X3

      Conserved Domains (1) summary
      cl22853
      Location:49 → 659
      Motor_domain; Myosin and Kinesin motor domain

    RNA

    1. XR_005489919.1 RNA Sequence

    2. XR_010055226.1 RNA Sequence

    3. XR_010055227.1 RNA Sequence

    4. XR_005489917.1 RNA Sequence

    5. XR_005489918.1 RNA Sequence

    6. XR_005489921.1 RNA Sequence

    7. XR_005489922.1 RNA Sequence

    8. XR_005489923.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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