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    Armc5 armadillo repeat containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 233912, updated on 8-May-2024

    Summary

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    Official Symbol
    Armc5provided by MGI
    Official Full Name
    armadillo repeat containing 5provided by MGI
    Primary source
    MGI:MGI:2384586
    See related
    Ensembl:ENSMUSG00000042178 AllianceGenome:MGI:2384586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Acts upstream of or within several processes, including T cell activation; adrenal cortex development; and defense response to virus. Located in membrane. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in ACTH-independent macronodular adrenal hyperplasia 2. Orthologous to human ARMC5 (armadillo repeat containing 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 30.3), thymus adult (RPKM 27.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Armc5 in Genome Data Viewer
    Location:
    7 F3; 7 70.06 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127836460..127844272)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (128237357..128245100)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene integrin, alpha D Neighboring gene RIKEN cDNA 4931431B13 gene Neighboring gene STARR-positive B cell enhancer ABC_E10479 Neighboring gene cytochrome c oxidase subunit 6A2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135380811-135380920 Neighboring gene STARR-positive B cell enhancer ABC_E2253 Neighboring gene STARR-positive B cell enhancer ABC_E8212 Neighboring gene zinc finger protein 696 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135396171-135396397 Neighboring gene transforming growth factor beta 1 induced transcript 1 Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 2 Neighboring gene RUS family member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Armc5 deletion causes developmental defects and compromises T-cell immune responses. Hu Y, et al. Nat Commun, 2017 Feb 7. PMID 28169274, Free PMC Article
    2. Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function. Berthon A, et al. Hum Mol Genet, 2017 Sep 15. PMID 28911199, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans.
      Title: ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans.
    2. Study on Armc5 knockout mice revealed that ARMC5 is crucial in fetal development and immune responses.
      Title: Armc5 deletion causes developmental defects and compromises T-cell immune responses.
    3. New mouse line can be used to study tissue-specific effects of Armc5. Armc5 haploinsufficiency leads to Cushing syndrome in mice, but only later in life, and this involves PKA, its catalytic subunit Calpha, and the Wnt/beta-catenin pathway.
      Title: Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36606, MGC102240

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within CD4-positive, alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within adrenal cortex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mesoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of steroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    armadillo repeat-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146205.2 → NP_666317.2  armadillo repeat-containing protein 5

      See identical proteins and their annotated locations for NP_666317.2

      Status: VALIDATED

      Source sequence(s)
      AK131111, BC025196
      Consensus CDS
      CCDS21892.1
      UniProtKB/Swiss-Prot
      Q5EBP3, Q6KAU6, Q8CDI5, Q8R3J0
      UniProtKB/TrEMBL
      Q8K287
      Related
      ENSMUSP00000040568.6, ENSMUST00000044660.6
      Conserved Domains (2) summary
      sd00043
      Location:145 → 177
      ARM; armadillo repeat [structural motif]
      cl38908
      Location:744 → 839
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127836460..127844272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153022.1 → XP_036008915.1  armadillo repeat-containing protein 5 isoform X1

      Conserved Domains (1) summary
      sd00043
      Location:145 → 177
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5EBP3.1 GenPept UniProtKB/Swiss-Prot:Q5EBP3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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