Arhgap15 Rho GTPase activating protein 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap15provided by MGI
Official Full Name: Rho GTPase activating protein 15provided by MGI
Primary source: MGI:MGI:1923367
See related: Ensembl:ENSMUSG00000049744 AllianceGenome:MGI:1923367
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5830480G12Rik
Summary: The protein encoded by this gene is a RAC GTPase-activating protein that is regulated through its PH domain and by recruitment to the membrane. The protein accelerates hydrolysis of guanosine triphosphate to guanosine diphosphate to repress Rac activity. Knock-out of Arhgap15 function demonstrates that this gene is required to regulate multiple functions in macrophages and neutrophils. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Expression: Broad expression in thymus adult (RPKM 1.0), cortex adult (RPKM 0.9) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 26.13 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (43638786..44285965)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (43748798..44395953)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ArhGAP15 role in the modulation of Rac1/Rac3 activity in the hippocampal inhibitory neurons.
Title: Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.
these results demonstrate the relevance of ArhGAP15 in the selective regulation of multiple neutrophil functions
Title: The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions.
Arhgap15 is associated with acute lung injury
Title: Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit154 (e-PCR), detects polymorphism
- UniSTS:129015

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 15

Names: rho-type GTPase-activating protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301831.1 → NP_001288760.1 rho GTPase-activating protein 15 isoform 3

See identical proteins and their annotated locations for NP_001288760.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK036520, AK040796, AL844535

Consensus CDS

CCDS79793.1

UniProtKB/TrEMBL

A0A2X0SSE2, B1AW40

Related

ENSMUSP00000108443.2, ENSMUST00000112824.8

Conserved Domains (3) summary

cd13233
Location:89 → 198

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:88 → 196

PH; PH domain

cl02570
Location:285 → 423

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_001301832.1 → NP_001288761.1 rho GTPase-activating protein 15 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternate exon in the 5' end of the transcript compared to variant 1. This causes translation initiation at a downstream AUG and results in an isoform (4) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK036520, AK040796, BF453909

Conserved Domains (2) summary

cd04403
Location:150 → 336

RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...

cl17171
Location:1 → 63

PH-like; Pleckstrin homology-like domain
NM_001364029.1 → NP_001350958.1 rho GTPase-activating protein 15 isoform 5

Status: REVIEWED

Source sequence(s)

AL732320, AL844535, AL845160, AL928611, AL935152

UniProtKB/TrEMBL

A0A2X0SSE2

Conserved Domains (2) summary

cd04403
Location:240 → 426

RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...

cd13233
Location:44 → 153

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
NM_153820.3 → NP_722542.2 rho GTPase-activating protein 15 isoform 1

See identical proteins and their annotated locations for NP_722542.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (1).

Source sequence(s)

AI840874, AK036520, AK040796, BC034881

Consensus CDS

CCDS16019.1

UniProtKB/Swiss-Prot

Q3T9M8, Q3TCU0, Q811M1, Q8C0I5, Q8JZY0

UniProtKB/TrEMBL

A0A2X0SSE2

Related

ENSMUSP00000056461.7, ENSMUST00000055776.8

Conserved Domains (3) summary

cd04403
Location:285 → 471

RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...

cd13233
Location:89 → 198

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:88 → 196

PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

43638786..44285965

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162663.1 → XP_036018556.1 rho GTPase-activating protein 15 isoform X3

UniProtKB/TrEMBL

A0A2X0SSE2

Conserved Domains (2) summary

cd13233
Location:89 → 198

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

cl02570
Location:285 → 387

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
XM_006498402.5 → XP_006498465.1 rho GTPase-activating protein 15 isoform X4

Conserved Domains (2) summary

cd13233
Location:89 → 198

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

cl02570
Location:285 → 404

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
XM_006498398.5 → XP_006498461.1 rho GTPase-activating protein 15 isoform X1

UniProtKB/TrEMBL

A0A2X0SSE2

Conserved Domains (2) summary

cd04403
Location:262 → 448

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:66 → 175

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
XM_006498399.5 → XP_006498462.1 rho GTPase-activating protein 15 isoform X2

See identical proteins and their annotated locations for XP_006498462.1

UniProtKB/TrEMBL

A0A2X0SSE2

Conserved Domains (2) summary

cd04403
Location:252 → 438

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:56 → 165

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
XM_006498403.3 → XP_006498466.1 rho GTPase-activating protein 15 isoform X5

See identical proteins and their annotated locations for XP_006498466.1

UniProtKB/TrEMBL

B2X2D4

Conserved Domains (1) summary

cd04403
Location:91 → 247

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001025377.1: Suppressed sequence

Description

NM_001025377.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.