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    Nanos3 nanos C2HC-type zinc finger 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288909, updated on 2-May-2024

    Summary

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    Official Symbol
    Nanos3provided by RGD
    Official Full Name
    nanos C2HC-type zinc finger 3provided by RGD
    Primary source
    RGD:1306672
    See related
    Ensembl:ENSRNOG00000031593 AllianceGenome:RGD:1306672
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in oogenesis; regulation of cell cycle; and regulation of translation. Predicted to act upstream of or within negative regulation of apoptotic signaling pathway; regulation of translation; and spermatogenesis. Predicted to be located in P-body; cytoplasmic stress granule; and nucleus. Predicted to be active in perinuclear region of cytoplasm. Orthologous to human NANOS3 (nanos C2HC-type zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 5.3), Uterus (RPKM 5.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nanos3 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40889531..40893699)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23978465..23988933)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25284907..25288680, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene microRNA 181c Neighboring gene microRNA 181d Neighboring gene break repair meiotic recombinase recruitment factor 1 Neighboring gene coiled-coil and C2 domain containing 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population. Lolicato F, et al. Dev Biol, 2008 Jan 15. PMID 18089289
    2. Conserved role of nanos proteins in germ cell development. Tsuda M, et al. Science, 2003 Aug 29. PMID 12947200
    3. Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. Bhandari D, et al. Genes Dev, 2014 Apr 15. PMID 24736845, Free PMC Article
    4. NANOS3 function in human germ cell development. Julaton VT, et al. Hum Mol Genet, 2011 Jun 1. PMID 21421998, Free PMC Article
    5. Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Suzuki H, et al. Dev Biol, 2008 Jun 1. PMID 18436203

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in germ cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within oogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nanos homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105945.1 → NP_001099415.1  nanos homolog 3

      See identical proteins and their annotated locations for NP_001099415.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IYA5, D4A138
      Related
      ENSRNOP00000045882.3, ENSRNOT00000050214.4
      Conserved Domains (1) summary
      pfam05741
      Location:57 → 109
      zf-nanos; Nanos RNA binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40889531..40893699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255235.5 → XP_006255297.1  nanos homolog 3 isoform X1

      Conserved Domains (1) summary
      pfam05741
      Location:57 → 109
      zf-nanos; Nanos RNA binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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