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    Elac2 elaC ribonuclease Z 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 282826, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Elac2provided by RGD
    Official Full Name
    elaC ribonuclease Z 2provided by RGD
    Primary source
    RGD:628882
    See related
    Ensembl:ENSRNOG00000003424 AllianceGenome:RGD:628882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 3'-tRNA processing endoribonuclease activity and tRNA-specific ribonuclease activity. Predicted to be involved in mitochondrial tRNA 3'-trailer cleavage, endonucleolytic. Predicted to be located in mitochondrial nucleoid and nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 17. Orthologous to human ELAC2 (elaC ribonuclease Z 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 108.7), Adrenal (RPKM 101.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elac2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (50131449..50154755)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (49632308..49655614)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (51478378..51501167)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480806 Neighboring gene uncharacterized LOC134480807 Neighboring gene Rho GTPase activating protein 44 Neighboring gene uncharacterized LOC134480809 Neighboring gene uncharacterized LOC134480808

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Naturally occurring mutations in human mitochondrial pre-tRNASer(UCN) can affect the transfer ribonuclease Z cleavage site, processing kinetics, and substrate secondary structure. Yan H, et al. J Biol Chem, 2006 Feb 17. PMID 16361254
    2. Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2. Dumont M, et al. Biochim Biophys Acta, 2004 Sep 17. PMID 15358515
    3. 3' processing of eukaryotic precursor tRNAs. Maraia RJ, et al. Wiley Interdiscip Rev RNA, 2011 May-Jun. PMID 21572561, Free PMC Article
    4. Localization of human RNase Z isoforms: dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation. Rossmanith W. PLoS One, 2011 Apr 29. PMID 21559454, Free PMC Article
    5. Functional analyses for tRNase Z variants: an aspartate and a histidine in the active site are essential for the catalytic activity. Elbarbary RA, et al. Biochim Biophys Acta, 2008 Dec. PMID 18809514

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-tRNA processing endoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-tRNA processing endoribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitochondrial tRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial tRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial tRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial tRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc phosphodiesterase ELAC protein 2
    Names
    RNase Z 2
    elaC homolog 2
    elaC homolog protein 2
    ribonuclease Z 2
    tRNA 3 endonuclease 2
    tRNase Z 2
    NP_758829.2
    XP_038941246.1
    XP_038941247.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172326.2 → NP_758829.2  zinc phosphodiesterase ELAC protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q8CGS5
      UniProtKB/TrEMBL
      A6HFE9, G3V6F5
      Related
      ENSRNOP00000004722.3, ENSRNOT00000004722.5
      Conserved Domains (2) summary
      cd07718
      Location:482 → 687
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cl23716
      Location:54 → 310
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      50131449..50154755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085319.1 → XP_038941247.1  zinc phosphodiesterase ELAC protein 2 isoform X2

      Conserved Domains (1) summary
      cl23716
      Location:54 → 310
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    2. XM_039085318.2 → XP_038941246.1  zinc phosphodiesterase ELAC protein 2 isoform X1

      Conserved Domains (2) summary
      cd07718
      Location:111 → 316
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cl23716
      Location:286 → 358
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGS5.1 GenPept UniProtKB/Swiss-Prot:Q8CGS5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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