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    Abce1 ATP binding cassette subfamily E member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361390, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Abce1provided by RGD
    Official Full Name
    ATP binding cassette subfamily E member 1provided by RGD
    Primary source
    RGD:1305301
    See related
    Ensembl:ENSRNOG00000018345 AllianceGenome:RGD:1305301
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Oabp; Rns4i
    Summary
    Predicted to enable several functions, including ATP binding activity; endoribonuclease inhibitor activity; and ribosomal small subunit binding activity. Predicted to be involved in negative regulation of endoribonuclease activity; ribosomal subunit export from nucleus; and translation. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to human ABCE1 (ATP binding cassette subfamily E member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 254.5), Thymus (RPKM 240.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abce1 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (45109880..45134819)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (28205566..28230489)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (31867960..31892863)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene Hedgehog-interacting protein Neighboring gene uncharacterized LOC134483635 Neighboring gene uncharacterized LOC102549584 Neighboring gene anaphase promoting complex subunit 10 Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene OTU deubiquitinase 4 Neighboring gene uncharacterized LOC102549652

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The expression profile of ATP-binding cassette transporter genes in breast carcinoma. Hlaváč V, et al. Pharmacogenomics, 2013 Apr. PMID 23556449
    2. Rustless translation. Hopfner KP. Biol Chem, 2012 Oct. PMID 23091275
    3. The role of ABC transporters in progression and clinical outcome of colorectal cancer. Hlavata I, et al. Mutagenesis, 2012 Mar. PMID 22294766
    4. Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs. Borel F, et al. Hepatology, 2012 Mar. PMID 21932399
    5. [Expression and clinical significance of ABCE1 in human lung adenocarcinoma]. Liu DZ, et al. Zhonghua Zhong Liu Za Zhi, 2008 Apr. PMID 18788636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables CTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endoribonuclease inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family E member 1
    Names
    ATP-binding cassette, sub-family E (OABP), member 1
    ATP-binding cassette, subfamily E (OABP), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108446.1 → NP_001101916.1  ATP-binding cassette sub-family E member 1

      See identical proteins and their annotated locations for NP_001101916.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A0A8I6GEV9, A6IYH8
      Related
      ENSRNOP00000024753.6, ENSRNOT00000024753.7
      Conserved Domains (1) summary
      COG1245
      Location:4 → 597
      Rli1; Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      45109880..45134819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255407.5 → XP_006255469.1  ATP-binding cassette sub-family E member 1 isoform X1

      See identical proteins and their annotated locations for XP_006255469.1

      UniProtKB/TrEMBL
      A0A8I6GEV9, A6IYH8
      Conserved Domains (1) summary
      COG1245
      Location:4 → 597
      Rli1; Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]

    2. XM_063278120.1 → XP_063134190.1  ATP-binding cassette sub-family E member 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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