Washc2c WASH complex subunit 2C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Washc2cprovided by RGD
Official Full Name: WASH complex subunit 2Cprovided by RGD
Primary source: RGD:735230
See related: Ensembl:ENSRNOG00000011653 AllianceGenome:RGD:735230
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam21; Fam21c; Washc2; NP61201
Summary: Predicted to enable phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and retromer complex binding activity. Predicted to be involved in several processes, including endosomal transport; negative regulation of barbed-end actin filament capping; and regulation of substrate adhesion-dependent cell spreading. Predicted to be located in cytosol; endosome; and nucleolus. Predicted to be part of WASH complex. Predicted to be active in early endosome. Orthologous to human WASHC2A (WASH complex subunit 2A) and WASHC2C (WASH complex subunit 2C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 299.6), Brain (RPKM 274.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (150912863..150998301)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (149267851..149325850)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (148139512..148197363)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-5-phosphate binding	ISO Inferred from Sequence Orthology more info
enables retromer complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables retromer complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of barbed-end actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in protein localization to endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to endosome	ISO Inferred from Sequence Orthology more info
involved_in protein localization to endosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of WASH complex	IBA Inferred from Biological aspect of Ancestor more info
part_of WASH complex	IEA Inferred from Electronic Annotation more info
part_of WASH complex	ISO Inferred from Sequence Orthology more info
part_of WASH complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WASH complex subunit 2

Names: WASH complex subunit FAM21; family with sequence similarity 21, member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199207.2 → NP_954677.2 WASH complex subunit 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q80X08

Related

ENSRNOP00000015620.6, ENSRNOT00000015620.7

Conserved Domains (1) summary

pfam15255
Location:946 → 1068

CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

150912863..150998301

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285891.1 → XP_063141961.1 WASH complex subunit 2 isoform X7
XM_039107431.2 → XP_038963359.1 WASH complex subunit 2 isoform X8

UniProtKB/Swiss-Prot

Q80X08

Conserved Domains (1) summary

pfam15255
Location:924 → 1046

CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
XM_039107428.2 → XP_038963356.1 WASH complex subunit 2 isoform X5

UniProtKB/Swiss-Prot

Q80X08

Conserved Domains (1) summary

pfam15255
Location:946 → 1068

CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
XM_063285890.1 → XP_063141960.1 WASH complex subunit 2 isoform X6

UniProtKB/Swiss-Prot

Q80X08
XM_006237147.5 → XP_006237209.1 WASH complex subunit 2 isoform X2

UniProtKB/Swiss-Prot

Q80X08

UniProtKB/TrEMBL

A0A8I6ADQ6

Related

ENSRNOP00000090531.1

Conserved Domains (1) summary

pfam15255
Location:925 → 1043

CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
XM_039107425.2 → XP_038963353.1 WASH complex subunit 2 isoform X1

UniProtKB/Swiss-Prot

Q80X08

Conserved Domains (1) summary

pfam15255
Location:945 → 1067

CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
XM_006237149.5 → XP_006237211.1 WASH complex subunit 2 isoform X4

UniProtKB/Swiss-Prot

Q80X08

UniProtKB/TrEMBL

A0A8I6AM40

Related

ENSRNOP00000096602.1

Conserved Domains (1) summary

pfam15255
Location:903 → 1030

CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
XM_039107426.2 → XP_038963354.1 WASH complex subunit 2 isoform X3

UniProtKB/Swiss-Prot

Q80X08

Conserved Domains (1) summary

pfam15255
Location:925 → 1047

CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region