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    Fbxl12 F-box and leucine-rich repeat protein 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313782, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Fbxl12provided by RGD
    Official Full Name
    F-box and leucine-rich repeat protein 12provided by RGD
    Primary source
    RGD:1305528
    See related
    Ensembl:ENSRNOG00000064355 AllianceGenome:RGD:1305528
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and entrainment of circadian clock by photoperiod. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Orthologous to human FBXL12 (F-box and leucine rich repeat protein 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 254.9), Spleen (RPKM 57.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxl12 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (27453042..27459136, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19175864..19183373, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (21656636..21662755, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 846 Neighboring gene uncharacterized LOC134480143 Neighboring gene ubiquitin-like 5 Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Neighboring gene olfactomedin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A family of mammalian F-box proteins. Winston JT, et al. Curr Biol, 1999 Oct 21. PMID 10531037
    2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112648

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025700.3 → NP_001020871.1  F-box/LRR-repeat protein 12 isoform 2

      See identical proteins and their annotated locations for NP_001020871.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZVJ2, A6JNK2, A6JNK4, Q4KM96
      Conserved Domains (2) summary
      cd09293
      Location:68 → 173
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:51 → 72
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. NM_001399819.2 → NP_001386748.1  F-box/LRR-repeat protein 12 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6JNK3, F7FJ48
      Related
      ENSRNOP00000061580.2, ENSRNOT00000068308.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      27453042..27459136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595608.3 → XP_017451097.1  F-box/LRR-repeat protein 12 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVJ2, A6JNK2, A6JNK4, Q4KM96
      Related
      ENSRNOP00000093235.1
      Conserved Domains (2) summary
      cd09293
      Location:68 → 173
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:51 → 72
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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